Cyanide Poisoning

Overview

Supplement evidence for cyanide poisoning centers on Vitamin B12 as hydroxocobalamin (brand Cyanokit), rated WA 68 with medium effect, evidence, and trust across four studies. It is given intravenously and is FDA-approved to treat cyanide toxicity from sources such as smoke inhalation and certain industrial exposures.

The available summary indicates it is considered safe for this use, including during pregnancy. No other supplements in this batch have evidence for cyanide poisoning. See the evidence reviews below for trial details and ratings.

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Vitamin B12	★★★★★	Medium

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Studies

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1 supplement for rated at least stars. All purchase bands. No minimum star filter.

Vitamin B12View supplement →

Consider purchase★★★★★

How we scored this

Effect SizeMediumEvidenceHighTrustHigh

Hospital IV/IM therapy — not an oral supplement

Evidence Review

Hydroxocobalamin (brand name Cyanokit) is a medicine given intravenously to treat poisoning by cyanide, a deadly chemical found in smoke and some industrial products.
It is safe and approved by the FDA for use in cyanide toxicity, even during pregnancy.

Browse 4 studies

Systematic reviewReview article: management of cyanide poisoning2012n=74

A systematic review of 74 studies found that no case series using dicobalt edetate or 4-dimethylaminophenol were identified, but successful use in single cases has been reported.

Effect: Benefit
Participants: 74

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Narrative reviewSmoke inhalation injury in a pregnant patient: a literature review of the evidence and current best practices in the setting of a classic case2012

A study in women found that although burned and presenting with concomitant smoke inhalation injury, both the woman and her child fared well with no significant complications due to the smoke inhalation at 6 months of follow-up.

Effect: Benefit
Population: Women

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Empiric management of cyanide toxicity associated with smoke inhalation2011

A study in adults found that prehospital studies have demonstrated the feasibility and safety of empiric treatment with hydroxocobalamin for patients with suspected smoke inhalation cyanide toxicity.

Population: Adults

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Clinical trialProspective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation2007n=42

A study of 42 adults found that 5 g hydroxocobalamin (max 15 g) empiric administration of hydroxocobalamin was associated with survival among 67% of patients confirmed a posteriori to have had cyanide poisoning.

Effect: Benefit
Dose: 5 g hydroxocobalamin (max 15 g)
Population: Adults
Participants: 42
Avg age: ~50

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

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Effect-size distribution

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Study distribution across 1 supplements for cyanide poisoning (hydroxocobalamin) (4 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Vitamin B12	★★★★★68%	4	0	100%

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