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SupplementDEX helps
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answer their patients' supplement questions with scientific confidence

Seamless clinical decision support

The best studies and supplement info. It's all here. Trust built-in. Every study human-reviewed.

Stop wasting hours reading PubMed.

Stop wasting hours reading PubMed articles that may or may not be relevant and answer your patient's supplement questions instantly with SupplementDEX.

SupplementDEX

This supplement is not effective. Weighted DEX Score: 40%

PubMed

91 studies incorporated into our analysis.

Science

7 studies incorporated into our analysis.

Cell

14 studies incorporated into our analysis.

Nature

9 studies incorporated into our analysis.

Trusted at point-of-care

Loved and trusted by consumers and teams from healthcare sectors like primary care, dietetics, pharmacy — evolving everyday to be your trusted supplement resource.

Patients ask about supplements every week. SupplementDEX gives me a clear verdict and the study trail in one place — I finally have something I trust to hand them.

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Maya C.

Primary care physician

I get dietary supplement questions daily. DEX Score cuts through the noise so my colleagues and I can recommend — or firmly discourage — without a literature rabbit hole.

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Jordan L.

Registered dietitian

The Simple vs Practitioner toggle is exactly what counselling needs. I can brief a patient in plain language, then dig into effect size and trust when a clinician asks.

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Samir O.

Clinical pharmacist

Creatine, fish oil, the usual gym stack — finally scored honestly. Proven vs reconsider beats another influencer thread.

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Elena B.

Sports dietitian

I used to buy whatever was trending. SupplementDEX stopped me wasting money on stuff with no evidence. The star ratings alone are worth bookmarking.

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Alex R.

Consumer

Condition pages with ranked supplements are a game-changer in clinic. Fast scan, human-verified summaries, citations when I need them.

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Priya N.

NP, women’s health

Patients ask about supplements every week. SupplementDEX gives me a clear verdict and the study trail in one place — I finally have something I trust to hand them.

avatar

Maya C.

Primary care physician

I get dietary supplement questions daily. DEX Score cuts through the noise so my colleagues and I can recommend — or firmly discourage — without a literature rabbit hole.

avatar

Jordan L.

Registered dietitian

The Simple vs Practitioner toggle is exactly what counselling needs. I can brief a patient in plain language, then dig into effect size and trust when a clinician asks.

avatar

Samir O.

Clinical pharmacist

Creatine, fish oil, the usual gym stack — finally scored honestly. Proven vs reconsider beats another influencer thread.

avatar

Elena B.

Sports dietitian

I used to buy whatever was trending. SupplementDEX stopped me wasting money on stuff with no evidence. The star ratings alone are worth bookmarking.

avatar

Alex R.

Consumer

Condition pages with ranked supplements are a game-changer in clinic. Fast scan, human-verified summaries, citations when I need them.

avatar

Priya N.

NP, women’s health

Patients ask about supplements every week. SupplementDEX gives me a clear verdict and the study trail in one place — I finally have something I trust to hand them.

avatar

Maya C.

Primary care physician

I get dietary supplement questions daily. DEX Score cuts through the noise so my colleagues and I can recommend — or firmly discourage — without a literature rabbit hole.

avatar

Jordan L.

Registered dietitian

The Simple vs Practitioner toggle is exactly what counselling needs. I can brief a patient in plain language, then dig into effect size and trust when a clinician asks.

avatar

Samir O.

Clinical pharmacist

Creatine, fish oil, the usual gym stack — finally scored honestly. Proven vs reconsider beats another influencer thread.

avatar

Elena B.

Sports dietitian

I used to buy whatever was trending. SupplementDEX stopped me wasting money on stuff with no evidence. The star ratings alone are worth bookmarking.

avatar

Alex R.

Consumer

Condition pages with ranked supplements are a game-changer in clinic. Fast scan, human-verified summaries, citations when I need them.

avatar

Priya N.

NP, women’s health

Patients ask about supplements every week. SupplementDEX gives me a clear verdict and the study trail in one place — I finally have something I trust to hand them.

avatar

Maya C.

Primary care physician

I get dietary supplement questions daily. DEX Score cuts through the noise so my colleagues and I can recommend — or firmly discourage — without a literature rabbit hole.

avatar

Jordan L.

Registered dietitian

The Simple vs Practitioner toggle is exactly what counselling needs. I can brief a patient in plain language, then dig into effect size and trust when a clinician asks.

avatar

Samir O.

Clinical pharmacist

Creatine, fish oil, the usual gym stack — finally scored honestly. Proven vs reconsider beats another influencer thread.

avatar

Elena B.

Sports dietitian

I used to buy whatever was trending. SupplementDEX stopped me wasting money on stuff with no evidence. The star ratings alone are worth bookmarking.

avatar

Alex R.

Consumer

Condition pages with ranked supplements are a game-changer in clinic. Fast scan, human-verified summaries, citations when I need them.

avatar

Priya N.

NP, women’s health

Powerful data visualization tools for the busy practitioner

Instantly see what works and doesn't

Need more detail? We have that too.

2600+ Evidence Reviews for 152 supplements

Creatine · Muscle mass & strength

Proven purchase★★★★★

How we scored this
Effect SizeHighEvidenceVery HighTrustVery High
Evidence Review
  • Oral creatine supplementation appears to modestly improve muscle strength.
  • Pooled analyses of clinical trials examining upper and lower limb strength and body composition have evaluated loading doses of 20 grams daily or 0.3 grams/kg daily for 5–7 days, with maintenance doses ranging from 1.25 to 27 grams daily for up to 32 weeks.
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Simple answers - maximum benefit for patient and practitioner

Patients can use SupplementDEX without complexity and prior knowledge.

Every supplement and condition on SupplementDEX has patient-friendly takeaways – embracing simplicity fully for those who just want an easy answer.

Red yeast rice

Hyperlipidemia · High Cholesterol

Practitioner Version

  • Red yeast rice (RYR) supplementation has demonstrated lipid-lowering effects in patients with hyperlipidemia, primarily due to its monacolin K content, which is chemically identical to lovastatin.
  • Clinical studies show that RYR at doses of 1–5 g daily (containing around 10 mg of total monacolin) for up to 24 weeks can decrease total cholesterol by up to 23% and LDL cholesterol by up to 34% versus placebo.
  • Meta-analyses of trials using RYR 100–4800 mg daily for up to 4.5 years report mean total cholesterol reductions of about 37 mg/dL, LDL reductions of 21–36 mg/dL, triglyceride decreases of 20–27 mg/dL, and HDL increases of approximately 3 mg/dL across populations with hyperlipidemia, cardiovascular disease, or hypertension.
  • Long-term support.SupplementDEX is the result of over a decade of development. Brought to life in 2026. We're here to stay.
  • Stop spending hours finding studies.Browse over 2600 evidence reviews by condition.
  • Rapid clinical decision support.Find what works. In seconds.