Cholestasis of pregnancy
Supplements studied for cholestasis of pregnancy.
Overview
SAMe is the main supplement studied for cholestasis of pregnancy, with nine trials. Oral or injectable SAMe appears comparable to ursodiol for easing itching, fatigue, and some liver test abnormalities in available head-to-head and parallel comparisons.
SAMe does not clearly outperform ursodiol in the available research, but it is among the better-studied options indexed for this liver condition of pregnancy. Trial quality, dosing, and routes of administration varied across studies. See the evidence reviews below for regimen and outcome detail.
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