SupplementDEX

Complex regional pain syndrome

Supplements studied for complex regional pain syndrome.

Overview

Vitamin C is the main supplement studied for complex regional pain syndrome (CRPS), with 10 trials mostly following wrist fracture. Daily vitamin C at roughly 500–1500 mg for about 50 days may lower CRPS risk in some studies, though results are not uniform across trials.

Intravenous Magnesium given for five days did not improve pain or disability in chronic CRPS type 1 compared with placebo in one trial. Preventive vitamin C evidence remains promising but not definitive. See the heatmap and evidence reviews below for trial detail.

Effect graph

Subscribe to access all content

Interactive visualisations of ranked conditions and clinical benefit with purchase guidance.

Get started for free

Already a subscriber? Sign in

Relevant supplements heatmap

Relevant supplements sorted by DEX Score.

Subscribe to access all content

See effect size, evidence strength, and trust at a glance for every condition.

Get started for free

Already a subscriber? Sign in

SupplementDEX Database

2 supplements for and rated at least stars. All purchase bands. No minimum star filter.

Subscribe to access all content

Read this and 2,600+ other evidence reviews on our practitioner plan.

Get started for free

Already a subscriber? Sign in

Evidence visualised

Subscribe to view condition evidence

Visual summaries of supplement evidence ranked by condition.

Get started for free

Already a subscriber? Sign in

On this page