Colic

Overview

Nattokinase is listed with four studies for infant colic, but the summarized evidence in this entry focuses mainly on dietary management rather than nattokinase itself. Switching to hypoallergenic formula may reduce crying compared with cow's milk formula in some infants, while soy formula benefit remains uncertain.

Direct nattokinase trial outcomes for colic are not summarized in this dataset, so its specific role cannot be assessed from this page. See the evidence reviews below for indexed trials and any updated summaries as they become available.

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Nattokinase	★★★★★	Low

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Studies

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NattokinaseView supplement →

Reconsider purchase★★★★★

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Evidence Review

Infant colic, characterized by excessive crying, can sometimes be managed by changing the baby’s diet or environment.
Using hypoallergenic formula instead of cow’s milk-based formula may help reduce crying.
The benefit of switching to soy formula is uncertain.
Medicines like dicyclomine can help but may have serious side effects, so they should be used cautiously.
Reducing stimulation around the baby may help calm them, but carrying them more may not reduce crying.
Over-the-counter gas drops like simethicone don’t appear to be helpful.

Browse 4 studies

MetaEffectiveness of treatments for infantile colic: systematic review1998

A systematic review found limited evidence that dietary changes or dicyclomine reliably treat infantile colic; fiber, osmotic laxatives, and some drugs had trial support.

Population: Infants

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RCTDietary modifications versus dicyclomine hydrochloride in the treatment of severe infantile colics1994n=120

An RCT in 120 infants (ages 3–12 weeks) with severe colic found hypoallergenic or soy formulas reduced symptoms versus dicyclomine in some subgroups.

Effect: Benefit
Duration: 3–12 weeks
Dose: 3 mg/kg
Population: Infants
Participants: 120
Ages: 3–12

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RCTDietary treatment of infant colic: a double-blind study1989

A double-blind crossover in 19 colicky infants found soy formula reduced colic duration during soy weeks versus cow's milk formula (11 of 19 met cow's milk intolerance criteria).

Effect: Benefit
Population: Infants

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Controlled trialCow's milk formula as a cause of infantile colic: a double-blind study1982n=22

In 60 colicky formula-fed infants, 18% were symptom-free on soy formula, 53% unchanged or worse on both formulas, and 29% had symptoms unrelated to diet; cow's milk intolerance was confirmed in 36% on challenge.

Effect: Benefit
Population: Infants
Participants: 22

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Study distribution across 1 supplements for colic (4 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Nattokinase	★★★★★52%	4	0	100%

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