Canker sores
Supplements studied for canker sores.
Overview
Canker sore supplement evidence is mixed across agents. Aloe products are often similar to standard gels in reviews, though one recent trial found a specific aloe gel outperformed amlexanox and placebo for pain and sore size.
Vitamin B12—both topical ointment and sublingual supplementation—may reduce pain and outbreak frequency in available studies, even when B12 levels are normal. Berberine gel reduced pain and ulcer size versus placebo in one trial. Multivitamins did not prevent sores in a year-long study, and beta-glucan evidence remains uncertain. See the heatmap and evidence reviews below for comparative trial detail.
Effect graph
Subscribe to access all content
Interactive visualisations of ranked conditions and clinical benefit with purchase guidance.
Already a subscriber? Sign in
Relevant supplements heatmap
Relevant supplements sorted by DEX Score.
Subscribe to access all content
See effect size, evidence strength, and trust at a glance for every condition.
Already a subscriber? Sign in
SupplementDEX Database
7 supplements for , and rated at least stars. All purchase bands. No minimum star filter.
Subscribe to access all content
Read this and 2,600+ other evidence reviews on our practitioner plan.
Already a subscriber? Sign in
Evidence visualised
Subscribe to view condition evidence
Visual summaries of supplement evidence ranked by condition.
Already a subscriber? Sign in