Chronic pain

Overview

Chronic pain supplement evidence is sparse and condition-dependent. A review of N-Acetyl Cysteine (NAC) in 863 patients across pain types likely found no meaningful pain or function benefit. Alpha-Lipoic Acid may reduce pain at 400–800 mg daily for two months in one mixed-etiology trial, but generalizability is limited.

Melatonin 3–12 mg daily produced a small pain reduction across heterogeneous conditions in one review. Vitamin D meta-analysis suggested early but not sustained pain differences versus placebo. See the heatmap and evidence reviews below for condition-specific detail.

Effect graph

Relevant supplements

Relevant supplements sorted by DEX Score.

Studies

Find individual evidence reviews for supplements sorted by DEX Score.

Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.