Pancreatic cancer risk

Overview

SupplementDEX currently indexes Vitamin B9 for pancreatic cancer risk. See the heatmap and evidence reviews below for the full rating.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Vitamin B9 (Folate)	★★★★★	Low

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Studies

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1 supplement for rated at least stars. All purchase bands. No minimum star filter.

Vitamin B9 (Folate)View supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceHighTrustMedium

Evidence Review

Eating more foods rich in folate (more than 280 mcg daily) is linked to a lower chance of developing pancreatic cancer.
Some studies suggest that women who consume higher amounts of folate have a reduced risk, but this benefit is not clearly seen in men.
Folate from foods appears to lower risk, while taking folic acid supplements does not have the same effect.
Researchers are still trying to understand these differences and why they may depend on sex or type of folate.

Browse 3 studies1 meta-analysis

ObservationalFolate intake and risk of pancreatic cancer: pooled analysis of prospective cohort studies2011n=319,716

A pooled analysis of 14 cohorts with 862,664 adults followed 7–20 years found no association between dietary or total folate intake and pancreatic cancer risk.

Effect: No Benefit
Population: Adults
Participants: 319,716
Ages: 7–20

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MetaFolate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis2006

A meta-analysis found that these findings support the hypothesis that folate may play a role in carcinogenesis of the esophagus, stomach, and pancreas.

Effect: Benefit

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ObservationalDietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers2001

In 27,101 male smokers aged 50–69, highest vs lowest dietary folate quintile was associated with 48% lower pancreatic cancer risk over up to 13 years (HR 0.52).

Effect: Benefit
Ages: 50–69

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

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Effect-size distribution

How large the reported benefits tend to be

Study distribution across 1 supplements for pancreatic cancer risk (3 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Vitamin B9 (Folate)	★★★★★52%	3	1	100%

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Overview

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Studies

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