Pregnancy outcomes

Overview

SupplementDEX lists 2 supplements studied for pregnancy outcomes across 5 trials. The strongest indexed signals include Multivitamin, Vitamin B9. See the heatmap and evidence reviews below for full ratings across all supplements.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Multivitamin	★★★★★	Low
Vitamin B9 (Folate)	★★★★★	Low

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Studies

Find individual evidence reviews for supplements sorted by DEX Score.

2 supplements for rated at least stars. All purchase bands. No minimum star filter.

MultivitaminView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceHighTrustMedium

Evidence Review

There is not enough evidence to determine if multivitamin supplementation has any benefit for pregnancy outcomes.

Browse 3 studies1 meta-analysis

Selecting a dietary supplement with appropriate dosing for 6 key nutrients in pregnancy2022

A review of prenatal supplement dosing found most products provide inadequate choline, iodine, vitamin D, and other key nutrients at labeled amounts.

Dose: 383–943 mg/day
Population: Women
Ages: 14–50

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MetaEffects of Maternal Nutritional Supplements and Dietary Interventions on Placental Complications: An Umbrella Review, Meta-Analysis and Evidence Map2021

A meta-analysis found maternal nutritional supplements modestly improved placental outcomes, with effects varying by nutrient and population.

Effect: Benefit
Population: Pregnant women

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RCTPreconception micronutrient supplementation positively affects child intellectual functioning at 6 y of age: A randomized controlled trial in Vietnam2021n=1,321

An RCT of 1,321 women found preconception micronutrient supplementation improved child intellectual development at follow-up versus control.

Effect: Benefit
Dose: 15 micronutrients weekly (preconception)
Population: Women
Participants: 1,321
Ages: 6–7

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Vitamin B9 (Folate)View supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceMediumTrustMedium

Evidence Review

Folic acid is very important for preventing neural tube defects, but it does not seem to improve most other pregnancy outcomes in a major way.
Research has not shown clear benefits for things like preterm birth or overall pregnancy course beyond its established role in folate support.

Browse 2 studies2 meta-analyses

MetaFolic acid supplementation in pregnancy to prevent preterm birth: a systematic review and meta-analysis of randomized controlled trials2016n=5,332

A meta-analysis of 5 RCTs in 5,332 women found folic acid supplementation did not reduce preterm birth before 37 weeks versus control (22.6% vs 22.9%).

Effect: No Benefit
Population: Women
Participants: 5,332

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MetaEffect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation2012

A meta-analysis of 10 RCTs found each two-fold increase in folate intake associated with ~2% higher birth weight; no effect on placental weight or gestational length.

Effect: Benefit
Population: Women

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 2 supplements for pregnancy outcomes (5 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Multivitamin	★★★★★52%	3	1	60%
Vitamin B9 (Folate)	★★★★★48%	2	2	40%

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Overview

Effect graph

Relevant supplements

Studies

Evidence visualised

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