Skin health

Overview

SupplementDEX lists 2 supplements studied for skin health across 6 trials. The strongest indexed signals include Vitamin B3, Vitamin K. See the heatmap and evidence reviews below for full ratings across all supplements.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Vitamin B3 (Niacin)	★★★★★	Low
Vitamin K	★★★★★	Very Low / None

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Studies

Find individual evidence reviews for supplements sorted by DEX Score.

2 supplements for and rated at least stars. All purchase bands. No minimum star filter.

Vitamin B3 (Niacin)View supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

Niacin (vitamin B3) has no meaningful benefit for Skin health.

Browse 2 studies

RCTNiacinamide: A B vitamin that improves aging facial skin appearance2005n=50

A randomized trial of 50 found that in addition to previously observed benefits for topical niacinamide, additional effects were identified (improved appearance of skin wrinkles and yellowing and improved elasticity).

Effect: Benefit
Duration: 12 weeks
Participants: 50

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RCTThe effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer2002n=120

A randomized trial of 120 women found that in the clinical studies, niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use.

Effect: Benefit
Duration: 4 weeks
Population: Women
Participants: 120

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Vitamin KView supplement →

Do not purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceMediumTrustMedium

Evidence Review

Vitamin K has no meaningful benefit for Skin health.

Browse 4 studies

RCTThe role of topical vitamin K oxide gel in the resolution of postprocedural purpura2009n=20

In an RCT of 20 participants, although differences in active versus placebo scores did not reach statistical significance during the nine-day study period, a trend toward faster resolution of purpura with the active product was seen.

Duration: 9 days
Population: Adults
Participants: 20

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Clinical trialLack of the effect of topical vitamin K on bruising after mechanical injury2004

A clinical trial found topical vitamin K did not reduce bruising after mechanical injury.

Effect: No Benefit

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RCTThe effects of topical vitamin K on bruising after laser treatment2002n=22

In an RCT of 22 participants, for 2 weeks, the side of the face treated with topical vitamin K before laser therapy showed no significant difference in bruising as compared to placebo.

Effect: No Benefit
Duration: 2 weeks
Population: Adults
Participants: 22

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RCTEffects of topical vitamin K and retinol on laser-induced purpura on nonlesional skin1999

In an RCT in adults, for 2 weeks, a combination of 1% vitamin K and 0.3% retinol in acrylates copolymer cream hastened the resolution of laser-induced purpura.

Effect: Benefit
Duration: 2 weeks
Population: Adults

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 2 supplements for skin health (6 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Vitamin K	★★★★★36%	4	0	67%
Vitamin B3 (Niacin)	★★★★★44%	2	0	33%

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Overview

Effect graph

Relevant supplements

Studies

Evidence visualised

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