SupplementDEX

Sepsis

Supplements studied for sepsis.

Overview

Vitamin C (30 studies) is the most studied supplement for sepsis, with high-quality trials finding that intravenous vitamin C does not reduce organ failure, hospital stays, or mortality—and one large study suggested possible harm. Melatonin (5 studies) may shorten ventilator time and hospital stay in adults but does not clearly improve survival; newborn data are mixed.

L-Carnitine (2 studies) does not reduce overall mortality but may benefit the sickest patients. N-Acetyl Cysteine (NAC) (2 studies) may improve breathing in septic shock without lowering death rates. See the heatmap and evidence reviews below.

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SupplementDEX Database

7 supplements for and rated at least stars. All purchase bands. No minimum star filter.

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