Skin wrinkles
Supplements studied for Skin wrinkles.
Overview
SupplementDEX lists 2 supplements studied for skin wrinkles across 10 trials. The strongest indexed signals include Vitamin A, Nattokinase. See the heatmap and evidence reviews below for full ratings across all supplements.
Effect graph
Relevant supplements
Relevant supplements sorted by DEX Score.
| Vitamin A | ★★★★★ | Medium |
| Nattokinase | ★★★★★ | Low |
Studies
Find individual evidence reviews for supplements sorted by DEX Score.
2 supplements for and rated at least stars. All purchase bands. No minimum star filter.
Vitamin AView supplement →
Consider purchase·★★★★★
How we scored this▸
- Topical vitamin A (retinol) creams can help improve signs of sun-related skin damage such as wrinkles, uneven tone, and roughness.
- Prescription tretinoin is a stronger form of vitamin A used by doctors to reduce fine wrinkles and dark spots, but it is not the same as over-the-counter retinol products.
- Research in women aged 35–65 shows that retinol creams can reduce wrinkles and roughness similarly to prescription tretinoin when used regularly for several months.
- In studies lasting 8–12 weeks, retinol creams with about 0.1% active ingredient reduced wrinkles, dark spots, and uneven texture compared with placebo.
Browse 8 studies
Clinical trialEfficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis2024n=5
A study of 5 women found that this pooled analysis of 6 vehicle-controlled clinical studies provides new evidence for the efficacy of 0.1% stabilized bioactive retinol in improving signs of photoaging without causing major irritation.
- Effect
- Benefit
- Duration
- 12 weeks
- Population
- Women
- Participants
- 5
- Avg age
- ~47
RCTA Double-Blind, Comparative Clinical Study of Newly Formulated Retinol Serums vs Tretinoin Cream in Escalating Doses: A Method for Rapid Retinization With Minimized Irritation2020
A randomized trial found that retinol serum (0.25%, 0.5%, 1.0%) was safe and effective with equivalent/or better performance and tolerability than tretinoin creams.
- Effect
- Benefit
- Duration
- 12 weeks
- Ages
- 35–65
RCTA randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%2012
A randomized trial found that there were no significant differences in efficacy between the two products for these assessments.
- Effect
- Benefit
- Duration
- 12 weeks
RCTImprovement of naturally aged skin with vitamin A (retinol)2007n=6
A 24-week RCT of 36 elderly adults (mean age 87) found topical 0.4% retinol improved fine wrinkling scores and increased dermal glycosaminoglycans and procollagen I versus vehicle on treated arms.
- Effect
- Benefit
- Duration
- 24 weeks
- Population
- Older adults
- Participants
- 6
- Avg age
- ~87
RCTTwo concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams1995n=35
A randomized trial of 35 patients with photoaging found that both 0.1% and 0.025% tretinoin produced statistically significant overall improvement in photoaging of the face compared with vehicle; there were no clinically or statistically significant differences in efficacy between the two concentrations of tretinoin.
- Effect
- Benefit
- Duration
- 48 weeks
- Population
- Patients With Photoaging
- Participants
- 35
RCTTopical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial1994
A randomized trial found that at the end of treatment, hyperpigmented lesions of the face and hands were lighter or much lighter in 90% of patients receiving tretinoin compared with 33% receiving vehicle (p < 0.0001).
- Effect
- Benefit
- Duration
- 40 weeks
- Population
- Adults
RCTTopical tretinoin for treatment of photodamaged skin. A multicenter study1991n=251
A randomized trial of 251 found that seventy-nine percent of the subjects who received 0.05% tretinoin for 24 weeks showed overall improvement in photodamaged skin compared with improvement in 48% of the vehicle-treated control subjects.
- Effect
- Benefit
- Duration
- 24 weeks
- Participants
- 251
RCTTopical tretinoin improves photoaged skin. A double-blind vehicle-controlled study1988n=30
A randomized trial of 30 found that fourteen of the 15 patients who received tretinoin to the face had improvement in photoaging, whereas none of the vehicle-treated patients' faces improved, a statistically significant difference in response between the two groups.
- Effect
- Benefit
- Population
- Adults
- Participants
- 30
NattokinaseView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- There is not enough evidence to determine if nattokinase has any benefit for skin wrinkles.
Browse 2 studies
RCTEfficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study2007n=65
In 65 women with photodamage, 12 weeks of soy moisturizer with protease inhibitors improved mottled pigmentation, blotchiness, fine lines, and overall appearance vs vehicle.
- Effect
- Benefit
- Duration
- 12 weeks
- Population
- Women
- Participants
- 65
RCTOral intake of soy isoflavone aglycone improves the aged skin of adult women2007n=26
In 26 women aged late 30s to early 40s, 40 mg/day soy isoflavone aglycone for 12 weeks improved fine wrinkles and malar skin elasticity vs placebo.
- Effect
- Benefit
- Duration
- 12 weeks
- Dose
- 40 mg/day
- Population
- Women
- Participants
- 26
Evidence visualised
Same ratings as above, aggregated so you can see coverage and imbalance.
| Supplement | DEX | Studies | Meta-analyses | Share |
|---|---|---|---|---|
| Vitamin A | ★★★★★68% | 8 | 0 | 80% |
| Nattokinase | ★★★★★44% | 2 | 0 | 20% |