Autoimmune thyroiditis
Supplements studied for Autoimmune thyroiditis.
Overview
SupplementDEX currently indexes Selenium for autoimmune thyroiditis. See the heatmap and evidence reviews below for the full rating.
Effect graph
Relevant supplements
Relevant supplements sorted by DEX Score.
| Selenium | ★★★★★ | Medium |
Studies
Find individual evidence reviews for supplements sorted by DEX Score.
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SeleniumView supplement →
Consider purchase·★★★★★
How we scored this▸
- Taking selenium supplements may help adults with autoimmune thyroiditis, especially Hashimoto's disease, by lowering certain thyroid antibodies that attack the thyroid gland.
- Selenium can also make some adults feel better, improving mood and well-being.
- It seems to work best when taken alongside thyroid hormone medicine and at doses up to 200 mcg daily.
- However, selenium does not appear to change thyroid hormone levels much and may not help children with this condition.
- More research is needed to confirm these effects in kids.
Browse 12 studies·3 meta-analyses
MetaClinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis2023n=342
A meta-analysis of 7 Hashimoto trials (342 patients) found selenium 200 mcg/day for 6 months significantly lowered TPOAb and TgAb, with inconsistent effects at 3 months.
- Effect
- Benefit
- Duration
- 6 months
- Dose
- 200 mcg/day
- Population
- Patients with Hashimoto thyroiditis
- Participants
- 342
RCTSelenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis2020n=18
In 40 euthyroid autoimmune thyroiditis patients, 200 mcg/day selenium for 3 months lowered TPOAb and oxidative stress markers versus placebo.
- Effect
- Benefit
- Duration
- 3 months
- Dose
- 200 mcg/day
- Population
- Healthy adults
- Participants
- 18
- Avg age
- 40.2±10.9
MetaSelenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis2016
A meta-analysis of 16 autoimmune thyroiditis trials found selenium supplementation significantly reduced TPOAb, especially at 3 and 6 months in levothyroxine-treated patients.
- Effect
- Benefit
- Duration
- 12 months
- Population
- Adults
- Ages
- 18+
Open-labelEffects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study2012n=30
In 23 euthyroid children with Hashimoto thyroiditis, 50 mcg/day selenium for 3 months did not change TPOAb or TgAb but was associated with thyroid volume regression in 35%.
- Effect
- No Benefit
- Duration
- 3 months
- Dose
- 50 mcg/day
- Population
- Children/adolescents
- Participants
- 30
- Avg age
- 12.3±2.4
RCTSelenium supplementation does not decrease thyroid peroxidase antibody concentration in children and adolescents with autoimmune thyroiditis2010n=18
In 49 children with autoimmune thyroiditis on levothyroxine for 12 months, selenium 100–200 mcg/day did not reduce TPOAb versus levothyroxine alone.
- Effect
- No Benefit
- Duration
- 12 months
- Dose
- 100 mcg/day
- Population
- Adults
- Participants
- 18
- Avg age
- 12.2±2.2
MetaSelenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis2010
A meta-analysis in Hashimoto patients on levothyroxine found selenium 200 mcg/day for 3 months significantly lowered TPOAb and improved mood versus placebo.
- Effect
- Benefit
- Duration
- 3 months
- Dose
- 200 mcg/day
- Population
- Patients with HT under LT₄ treatment
Controlled trial[The effect of selenium therapy on autoimmune thyroiditis]2008n=70
In 132 autoimmune thyroiditis patients over 1 year, L-selenomethionine 200 mcg/day reduced antithyroid peroxidase antibodies versus placebo alongside levothyroxine.
- Effect
- Benefit
- Duration
- 1 year
- Dose
- 200 mcg/day
- Population
- Patients with autoimmune thyroiditis
- Participants
- 70
- Avg age
- ~41
Clinical trialEffects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis2007n=40
In 80 women with Hashimoto thyroiditis, 200 mcg/day selenium for 6 months reduced anti-TPO by 21%; stopping selenium led to antibody rebound.
- Effect
- Benefit
- Duration
- 6 months
- Dose
- 200 mcg/day
- Population
- Women
- Participants
- 40
- Ages
- 24–52
RCTSelenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses2006n=88
In 88 women with autoimmune thyroiditis over 9 months, L-selenomethionine 200 mcg/day suppressed TPOAb, with doses above 100 mcg/day needed for sustained effect.
- Effect
- Benefit
- Duration
- 9 months
- Dose
- 200 mcg/day
- Population
- Patients with AIT (mean age = 40
- Participants
- 88
- Avg age
- 40.1±13.3
RCTEffects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis2003n=34
In 65 autoimmune thyroiditis patients over 6 months, selenomethionine 200 mcg/day plus levothyroxine lowered TPOAb versus levothyroxine plus placebo.
- Effect
- Benefit
- Dose
- 200 mcg/day
- Population
- Patients with autoimmune thyroiditis
- Participants
- 34
- Ages
- 22–61
RCTSelenium in the treatment of autoimmune thyroiditis2003n=14
In 47 autoimmune thyroiditis patients followed 6 months, continuing sodium selenite 200 mcg/day further lowered TPOAb, while stopping selenium raised antibody levels.
- Effect
- Benefit
- Dose
- 200 mcg/day
- Population
- Patients with autoimmune thyroiditis reduced thyroid peroxidase
- Participants
- 14
RCTSelenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations2002n=70
In 70 women with autoimmune thyroiditis over 3 months, sodium selenite 200 mcg/day reduced TPOAb and improved thyroid ultrasound patterns versus placebo with levothyroxine.
- Effect
- Benefit
- Duration
- 3 months
- Dose
- 200 mcg/day
- Population
- Patients with autoimmune thyroiditis decreases thyroid peroxidas
- Participants
- 70
- Avg age
- ~48
Evidence visualised
Same ratings as above, aggregated so you can see coverage and imbalance.
| Supplement | DEX | Studies | Meta-analyses | Share |
|---|---|---|---|---|
| Selenium | ★★★★★68% | 12 | 3 | 100% |