Acute liver failure

Overview

SupplementDEX currently indexes N-Acetyl Cysteine for acute liver failure. See the heatmap and evidence reviews below for the full rating.

Effect graph

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N-Acetyl Cysteine (NAC)	★★★★★	Very Low / None

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Studies

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1 supplement for rated at least stars. All purchase bands. No minimum star filter.

N-Acetyl Cysteine (NAC)View supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceHighTrustMedium

Evidence Review

There is not enough evidence to determine if N-acetyl cysteine has any benefit for acute liver failure.

Browse 3 studies3 meta-analyses

RCTNo Significant Beneficial Effects of Intravenous N-Acetylcysteine on Patient Outcome in Non-Paracetamol Acute Liver Failure: A Meta-Analysis of Randomized Controlled Trials2024

An RCT in critically ill patients found intravenous NAC did not significantly improve patient outcomes or reduce organ failure versus standard care.

Effect: No Benefit
Population: Adults

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MetaN-acetylcysteine in non-acetaminophen-induced acute liver failure: a systematic review and meta-analysis of prospective studies2022n=672

A systematic review found NAC may improve outcomes in non-acetaminophen acute liver failure, but evidence quality was low and results inconsistent.

Effect: Benefit
Population: Acute liver failure patients
Participants: 672

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RCTEfficacy and safety of N-acetylcysteine for the treatment of non-acetaminophen-induced acute liver failure: an updated systematic review and meta-analysis2021

An RCT found NAC was safe for non-acetaminophen-induced acute liver failure but did not significantly improve survival versus standard care.

Effect: No Benefit
Population: Adults

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 1 supplements for acute liver failure (3 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
N-Acetyl Cysteine (NAC)	★★★★★40%	3	3	100%

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Overview

Effect graph

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Studies

Evidence visualised

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