Mouth sores (Oral leukoplakia)

Overview

SupplementDEX currently indexes Vitamin E for mouth sores (oral leukoplakia). See the heatmap and evidence reviews below for the full rating.

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Vitamin E	★★★★★	Low

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Studies

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Vitamin EView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

Taking vitamin E by mouth does not lower the chance of developing oral leukoplakia (white patches in the mouth) in male smokers.
The study showed that daily vitamin E for 5 to 7 years did not change the appearance of these mouth lesions compared to placebo.

Browse 2 studies

RCTLong-term supplementation with alpha-tocopherol and beta-carotene and prevalence of oral mucosal lesions in smokers1998

In an RCT in cancer patients, 50 mg/day, the present study on oral health does not support the hypothesis that alpha-tocopherol or beta-carotene supplementation plays an essential role in preventing oral mucosal changes in smokers.

Effect: No Benefit
Dose: 50 mg/day
Population: Cancer patients
Ages: 55–74

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Clinical trialRegression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study1993n=43

In a clinical trial of 43 participants, 400 IU/day, for 24 weeks, the efficacy of alpha-tocopherol alone and in combination with other chemopreventive agents for carcinogenesis in the upper aerodigestive tract should be explored in future trials.

Effect: Benefit
Duration: 24 weeks
Dose: 400 IU/day
Population: Cancer patients
Participants: 43

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