Mental resilience

Overview

Rhodiola has medium-strength evidence from six studies and is possibly effective for mental resilience. Tyrosine has insufficient evidence from two studies, and Yohimbe lacks sufficient evidence from a single trial.

Overall, rhodiola stands out among the three supplements reviewed, though tyrosine and yohimbe cannot be recommended based on current data. The heatmap and evidence reviews below compare these supplements.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Rhodiola	★★★★★	Medium
Tyrosine	★★★★★	Low
Yohimbe	★★★★★	Very Low / None

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Studies

Find individual evidence reviews for supplements sorted by DEX Score.

3 supplements for , and rated at least stars. All purchase bands. No minimum star filter.

RhodiolaView supplement →

Consider purchase★★★★★

How we scored this

Effect SizeMediumEvidenceHighTrustHigh

Evidence Review

Rhodiola is possibly effective for Mental resilience.

Browse 6 studies1 meta-analysis

RCTEffects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men2018n=26

In hospitalized patients on antibiotics, S. boulardii reduced AAD incidence versus placebo in a single-center randomized trial.

Effect: Benefit
Duration: 4 weeks
Dose: 600 mg/day
Population: Men
Participants: 26

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RCTThe influence of adaptogens on ultraweak biophoton emission: a pilot-experiment2009n=10

In 30 adults, Rhodiola rosea or ADAPT-232 altered ultra-weak photon emission versus placebo in a pilot adaptogen study.

Effect: Benefit
Duration: 1 week
Population: Adults
Participants: 10

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RCTA randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue2008n=30

In 60 adults with stress-related fatigue, SHR-5 Rhodiola rosea improved fatigue, concentration, and stress symptoms versus placebo.

Effect: Benefit
Duration: 28 days
Dose: 576 mg/day SHR-5 extract
Population: Adults
Participants: 30
Ages: 20–55

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RCTA randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work2003

In 180 hospitalized patients, S. boulardii reduced antibiotic-associated diarrhea to 9.5% versus 22% on placebo.

Effect: Benefit
Ages: 19–21

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RCTA double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen2000

A meta-analysis of 9 probiotic trials found S. boulardii and lactobacilli reduced antibiotic-associated diarrhea versus placebo.

Effect: Benefit
Duration: 20 days

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RCTRhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty2000

Updated IDSA/SHEA guidelines recommend probiotics only selectively for C. difficile prevention; S. boulardii evidence was noted but not strongly endorsed.

Effect: Benefit

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TyrosineView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

Evidence is insufficient for this condition for Mental resilience.

Browse 2 studies

RCTThe catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress2014n=36

An RCT of 78 military personnel found that 300 mg/kg tyrosine during SERE stress training increased anger ratings but did not alter most mood, cortisol, or heart rate responses.

Effect: No Benefit
Dose: 300 mg/kg
Population: Adults
Participants: 36
Avg age: 25±4

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Controlled trialTreatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans1989

A crossover study found that 100 mg/kg tyrosine significantly reduced symptoms, adverse moods, and performance impairments during 4.5 hours of cold and hypoxia exposure in stress-sensitive subjects.

Effect: Benefit
Dose: 100 mg/kg

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YohimbeView supplement →

Do not purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceLowTrustMedium

Evidence Review

Evidence is insufficient for this condition.

Browse 1 study

RCTPsychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controls2011n=12

In 12 endurance athletes and 12 untrained controls, 0.4 mg/kg yohimbine and social stress raised anxiety, cortisol, heart rate, and blood pressure similarly in both groups, refuting blunted adrenergic reactivity in trained athletes.

Effect: No Benefit
Dose: 0.4 mg/kg/day
Population: Athletes
Participants: 12

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 3 supplements for mental resilience (9 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Rhodiola	★★★★★68%	6	1	67%
Tyrosine	★★★★★44%	2	0	22%
Yohimbe	★★★★★32%	1	0	11%

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Overview

Effect graph

Relevant supplements

Studies

Evidence visualised

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