Migraine
Supplements studied for migraine.
Overview
Caffeine combined with pain relievers like acetaminophen and aspirin has high-strength evidence for acute migraine treatment across 10 studies. Melatonin at 3 to 4 mg in the evening, Vitamin B2 (Riboflavin) at 100 to 400 mg daily, and Coenzyme Q10 at 100 to 400 mg daily have medium-strength evidence for prevention, reducing attack frequency, duration, or severity.
Vitamin D supplementation shows preliminary but uncertain preventive benefit in small trials. The heatmap and evidence reviews below compare these options across 70 studies.
Effect graph
Subscribe to access all content
Interactive visualisations of ranked conditions and clinical benefit with purchase guidance.
Already a subscriber? Sign in
Relevant supplements heatmap
Relevant supplements sorted by DEX Score.
Subscribe to access all content
See effect size, evidence strength, and trust at a glance for every condition.
Already a subscriber? Sign in
SupplementDEX Database
16 supplements for , and rated at least stars. All purchase bands. No minimum star filter.
Subscribe to access all content
Read this and 2,600+ other evidence reviews on our practitioner plan.
Already a subscriber? Sign in
Evidence visualised
Subscribe to view condition evidence
Visual summaries of supplement evidence ranked by condition.
Already a subscriber? Sign in