Morning sickness
Supplements studied for morning sickness.
Overview
Oral Ginger may modestly reduce nausea during pregnancy based on 14 studies with medium-strength evidence for effect size, evidence, and trust. The research is still limited, and more studies are needed to know how reliable the benefit is.
See the evidence reviews below for details on dosing and outcomes across these trials.
Effect graph
Relevant supplements
Relevant supplements sorted by DEX Score.
| Ginger | ★★★★★ | Medium |
Studies
Find individual evidence reviews for supplements sorted by DEX Score.
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GingerView supplement →
Consider purchase·★★★★★
How we scored this▸
- Oral ginger may modestly reduce nausea during pregnancy.
- The research is still limited, so more studies are needed to know how reliable the benefit is.
Browse 14 studies·3 meta-analyses
MetaEffect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis2022n=1,174
A meta-analysis of 1,174 pregnant women found ginger significantly more effective than placebo for reducing nausea and vomiting, with efficacy comparable to vitamin B6.
- Effect
- Benefit
- Population
- Women
- Participants
- 1,174
MetaA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting2014
A systematic review and meta-analysis found ginger significantly reduced nausea and vomiting in pregnancy versus placebo, with no increase in adverse pregnancy outcomes.
- Effect
- Benefit
- Dose
- 1500 mg/day
- Population
- Women
MetaEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis2014n=508
A meta-analysis of 508 pregnant women found ginger 1 g/day significantly reduced nausea and vomiting in early pregnancy versus placebo (pooled OR favoring ginger).
- Effect
- Benefit
- Dose
- 1 g/day
- Population
- Pregnant women
- Participants
- 508
RCTComparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea2011
In pregnant women with nausea, ginger was comparably effective to metoclopramide for reducing nausea and vomiting severity in a double-blind randomized trial.
- Effect
- Benefit
- Population
- Women
MetaInterventions for nausea and vomiting in early pregnancy2010n=4,041
A Cochrane review of interventions for early pregnancy nausea found ginger more effective than placebo for reducing nausea and vomiting, though evidence quality was moderate.
- Effect
- Benefit
- Population
- Women
- Participants
- 4,041
RCTA randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy2007n=85
In 170 pregnant women, ginger 1 g/day was as effective as dimenhydrinate 100 mg/day for reducing nausea and vomiting in a double-blind RCT.
- Effect
- Benefit
- Dose
- 50 mg 2×/day
- Population
- Women
- Participants
- 85
RCTComparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial2007
In 126 pregnant women with nausea, ginger 650 mg three times daily for 4 days was as effective as vitamin B6 25 mg three times daily for symptom relief.
- Effect
- Benefit
- Duration
- 4 days
- Dose
- 1950 mg/day
- Population
- Women
Systematic reviewEffectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting2005n=429
A systematic review of 6 trials (429 pregnant women) found ginger more effective than placebo for pregnancy nausea and vomiting, with no teratogenic signals identified.
- Effect
- Benefit
- Population
- Women
- Participants
- 429
RCTEffect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial2003n=120
In 120 pregnant women with morning sickness, ginger extract 125 mg four times daily for 4 days significantly reduced nausea, vomiting, and retching scores versus placebo.
- Effect
- Benefit
- Duration
- 4 days
- Dose
- 125 mg/day
- Population
- Women
- Participants
- 120
ObservationalProspective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy2003
In a prospective cohort of pregnant women taking ginger for NVP, outcomes were comparable to non-antiemetic controls; patients rated ginger moderately effective for symptom relief.
- Effect
- Benefit
- Population
- Women
- Avg age
- 39±2
RCTGinger syrup as an antiemetic in early pregnancy2002n=26
In 26 pregnant women in the first trimester, ginger syrup 1 tablespoon daily for 2 weeks significantly reduced nausea symptoms versus placebo.
- Effect
- Benefit
- Duration
- 2 weeks
- Dose
- 1 g/day
- Population
- Women
- Participants
- 26
RCTGinger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial2001
In 70 pregnant women with nausea and vomiting, ginger 1 g/day for 4 days significantly reduced nausea visual analogue scores versus placebo in a double-blind trial.
- Effect
- Benefit
- Duration
- 5 months
- Dose
- 1 g/day
- Population
- Women
Systematic reviewInterventions for nausea and vomiting in early pregnancy2000
An early Cochrane review of 20 trials found ginger more effective than placebo for reducing nausea and vomiting in early pregnancy, though study quality was variable.
- Effect
- Benefit
- Population
- Women
RCTGinger treatment of hyperemesis gravidarum1991n=30
In 27 women with hyperemesis gravidarum, ginger 250 mg four times daily for 4 days significantly reduced vomiting episodes versus placebo in a crossover trial.
- Effect
- Benefit
- Duration
- 4 days
- Dose
- 1000 mg/day
- Population
- Women
- Participants
- 30
Evidence visualised
Same ratings as above, aggregated so you can see coverage and imbalance.
| Supplement | DEX | Studies | Meta-analyses | Share |
|---|---|---|---|---|
| Ginger | ★★★★★68% | 14 | 3 | 100% |