Hypertriglyceridemia (High triglyceride levels)

Overview

SupplementDEX currently indexes Alpha Lipoic Acid for hypertriglyceridemia (high triglyceride levels). See the heatmap and evidence reviews below for the full rating.

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Alpha-Lipoic Acid	★★★★★	Low

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Studies

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Alpha-Lipoic AcidView supplement →

Reconsider purchase★★★★★

How we scored this

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Evidence Review

Studies show that taking alpha-lipoic acid by mouth usually does not lower high triglyceride levels, but it might help some groups.
In overweight adults, 600 mg daily for 24 weeks did not lower triglycerides.
A review of 11 studies found no benefit from doses between 300 and 1200 mg daily.
One small study in pregnant women with diabetes found that taking 100 mg daily for 8 weeks lowered triglycerides by 30 mg/dL, but the study was short.

Browse 3 studies1 meta-analysis

RCTA Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations2020n=81

In 81 overweight adults with elevated triglycerides, (R)-alpha-lipoic acid 600 mg/day for 24 weeks did not lower triglycerides but reduced BMI, body fat (especially in women and obese participants), and oxidative stress markers.

Effect: No Benefit
Duration: 24 weeks
Dose: 600 mg/day
Population: Women
Participants: 81
Ages: 21–60

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Clinical trialEffect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study2020n=30

8-week clinical trial in 60 gestational diabetes women given 100 mg/day ALA lowered triglycerides, TyG index, and atherogenic index versus placebo.

Effect: Benefit
Dose: 100 mg/day
Population: Women
Participants: 30
Ages: 18–40

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MetaDoes alpha-lipoic acid affect lipid profile? A meta-analysis and systematic review on randomized controlled trials2019

A meta-analysis of 11 RCTs found alpha-lipoic acid significantly lowered total cholesterol and LDL cholesterol versus placebo, with triglyceride reductions in diabetic and non-diabetic subgroups.

Effect: Benefit
Dose: 1200 mg/day

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