Breast cancer
Supplements studied for breast cancer.
Overview
SupplementDEX indexes 22 supplements for breast cancer across 86 studies.
Soy isoflavones from foods such as natto (WA 60) may be linked to lower breast cancer risk in observational research, but post-diagnosis soy intake shows mixed results. Olive Oil (WA 68; medium effect size, high evidence, high trust) in the diet may also reduce breast cancer risk in most indexed research.
Calcium (WA 52; low effect size, high evidence, medium trust) and Vitamin E supplements (WA 40) do not appear to prevent breast cancer in large trials. Black Tea (WA 36; very low effect size, medium evidence, medium trust) shows no risk reduction. See the heatmap and evidence reviews below for all 22 supplements.
Effect graph
Relevant supplements
Relevant supplements sorted by DEX Score.
| Olive Oil | ★★★★★ | Medium |
| Nattokinase | ★★★★★ | Medium |
| Green Tea | ★★★★★ | Low |
| Vitamin A | ★★★★★ | Low |
| Flaxseed | ★★★★★ | Low |
| Calcium | ★★★★★ | Low |
| Methionine | ★★★★★ | Low |
| Melatonin | ★★★★★ | Low |
| Vitamin D | ★★★★★ | Very Low / None |
| Resveratrol | ★★★★★ | Low |
| Reishi | ★★★★★ | Low |
| Zeaxanthin | ★★★★★ | Low |
| Vitamin K | ★★★★★ | Low |
| Vitamin E | ★★★★★ | Very Low / None |
| Vitamin B9 (Folate) | ★★★★★ | Very Low / None |
| Lutein | ★★★★★ | Low |
| Garlic | ★★★★★ | Low |
| Gamma-Linolenic Acid | ★★★★★ | Low |
| Flaxseed Oil | ★★★★★ | Low |
| American Ginseng | ★★★★★ | Low |
| Oleic Acid | ★★★★★ | Very Low / None |
| Multivitamin | ★★★★★ | Very Low / None |
| Black Tea | ★★★★★ | Very Low / None |
| Panax Ginseng | ★★★★★ | Very Low / None |
| Vitamin C | ★★★★★ | Very Low / None |
Studies
Find individual evidence reviews for supplements sorted by DEX Score.
25 supplements for , and rated at least stars. All purchase bands. No minimum star filter.
NattokinaseView supplement →
Consider purchase·★★★★★
How we scored this▸
- Soy foods like natto contain natural compounds called isoflavones that can act like estrogen in the body.
- Research suggests that eating more soy may lower the risk of breast cancer in both younger and older women.
- However, studies looking at soy supplements or soy intake after breast cancer diagnosis have shown mixed results.
- Eating whole soy foods as part of a balanced diet might be beneficial, but it's best to consult your healthcare provider about soy intake if you have breast cancer or are at risk.
Browse 18 studies·4 meta-analyses
MetaSoy Isoflavones and Breast Cancer Risk: A Meta-analysis2022
A meta-analysis found higher soy isoflavone intake associated with lower breast cancer risk, with effects varying by menopausal status and study design.
- Effect
- Benefit
- Population
- Women
ObservationalDietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry2017n=6,235
In 6235 breast cancer survivors, higher dietary isoflavone intake was associated with lower all-cause mortality, especially in women with ER-negative tumors.
- Effect
- Benefit
- Duration
- ~9.4 years
- Population
- Women
- Participants
- 6,235
RCTDouble-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density2015n=66
A 12-month double-blind RCT in 66 treated breast cancer patients and 29 high-risk women found daily soy (50 mg isoflavones) did not change breast MRI density or mammographic density.
- Effect
- No Benefit
- Duration
- 12 months
- Population
- Postmenopausal women
- Participants
- 66
MetaAssociation between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women: a meta-analysis of epidemiological studies2014
A meta-analysis of 35 studies found soy isoflavone intake associated with lower breast cancer risk in both pre- and postmenopausal women, with stronger effects in Asian populations.
- Effect
- Benefit
- Population
- Postmenopausal women
ObservationalDietary isoflavone intake is not statistically significantly associated with breast cancer risk in the Multiethnic Cohort2014n=84,450
In 84,450 women from the Multiethnic Cohort, dietary isoflavone intake was not statistically significantly associated with breast cancer risk.
- Effect
- No Benefit
- Dose
- 7 mg/day
- Population
- Women
- Participants
- 84,450
MetaPost-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies2013n=11,206
A meta-analysis of 5 cohorts (11,206 breast cancer patients) found higher post-diagnosis soy intake associated with lower all-cause mortality but not breast cancer-specific mortality.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 11,206
RCTSoy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women2012
In 9514 US and Chinese breast cancer survivors, higher post-diagnosis soy food intake was associated with lower recurrence and mortality.
- Effect
- Benefit
- Population
- Women
ObservationalA prospective study of vegetarianism and isoflavone intake in relation to breast cancer risk in British women2008n=585
In 37,643 British EPIC women, vegetarianism and isoflavone intake were not clearly associated with lower breast cancer risk.
- Effect
- No Benefit
- Dose
- 10.8 mg/day
- Population
- Postmenopausal women
- Participants
- 585
MetaSoyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies2006
A meta-analysis of observational studies found higher soyfood or isoflavone intake associated with modestly lower breast cancer risk in women.
- Effect
- Benefit
- Population
- Women
Clinical trialA pilot clinical study of short-term isoflavone supplements in breast cancer patients2004n=17
A pilot trial in 17 newly diagnosed breast cancer patients found short-term isoflavone supplements did not accelerate tumor proliferation markers before surgery.
- Effect
- No Benefit
- Population
- Breast cancer patients
- Participants
- 17
Dietary phytoestrogens and breast cancer risk2004n=280
In 15,555 Dutch EPIC women (ages 49–70), higher phytoestrogen intake was not clearly associated with lower breast cancer risk.
- Effect
- No Benefit
- Population
- Women
- Participants
- 280
- Ages
- 49–70
ObservationalPhyto-oestrogen intake and breast cancer risk in South Asian women in England: findings from a population-based case-control study2004
A UK case-control study in South Asian women found phyto-oestrogen intake from pulses and vegetables was not clearly linked to breast cancer risk.
- Effect
- No Benefit
- Population
- Women
ObservationalSoy, isoflavones, and breast cancer risk in Japan2003n=179
In 21,852 Japanese women from the JPHC study, higher isoflavone consumption was associated with lower breast cancer risk, especially in postmenopausal women.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 179
- Ages
- 40–59
ObservationalSoyfood intake during adolescence and subsequent risk of breast cancer among Chinese women2001
A Chinese case-control study found higher adolescent soyfood intake associated with lower premenopausal breast cancer risk later in life.
- Effect
- Benefit
- Population
- Postmenopausal women
- Ages
- 13–15
RCTEffects of soy foods on ovarian function in premenopausal women2000n=20
A 7-month soy intervention in 20 premenopausal women (32 mg/day isoflavones) altered menstrual cycle length but did not clearly suppress ovarian estrogen production.
- Effect
- No Benefit
- Dose
- 32 mg/day
- Population
- Women
- Participants
- 20
ObservationalTofu and risk of breast cancer in Asian-Americans1996
An Asian-American case-control study found tofu intake was not clearly associated with breast cancer risk after migration-related dietary changes.
- Effect
- No Benefit
- Population
- Postmenopausal women
ObservationalMigration patterns and breast cancer risk in Asian-American women1993
A case-control study found breast cancer risk rose across generations in Asian-American women migrating to the US, consistent with westernization of diet and lifestyle.
- Population
- Women
- Ages
- 20–55
ObservationalDietary effects on breast-cancer risk in Singapore1991
A Singapore case-control study of 200 breast cancer cases found high animal protein and red meat intake linked to higher premenopausal breast cancer risk.
- Population
- Postmenopausal women
Olive OilView supplement →
Consider purchase·★★★★★
How we scored this▸
- Most research finds that including olive oil in the diet may help reduce breast cancer risk.
Browse 5 studies·2 meta-analyses
MetaOlive oil intake and cancer risk: A systematic review and meta-analysis2022n=929,771
A meta-analysis of 929,771 subjects found highest vs lowest olive oil consumption associated with 31% lower overall cancer likelihood, including breast and gastrointestinal cancers.
- Effect
- Benefit
- Participants
- 929,771
MetaOlive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies2011n=13,800
A meta-analysis of 19 observational studies (13,800 cancer patients) found highest vs lowest olive oil intake associated with lower odds of any cancer (OR 0.59) and breast cancer.
- Effect
- Benefit
- Population
- Adults
- Participants
- 13,800
ObservationalConsumption of olive oil and specific food groups in relation to breast cancer risk in Greece1995n=820
In 820 Greek breast cancer cases vs controls, olive oil consumption showed an inverse trend with breast cancer risk (OR 0.87 per 30 g/day increment, P = 0.03).
- Effect
- Benefit
- Dose
- 30 g/day
- Population
- Postmenopausal women
- Participants
- 820
ObservationalOlive oil, other dietary fats, and the risk of breast cancer (Italy)1995n=2,588
In 2564 Italian breast cancer cases vs 2588 controls, each 30 g/day increment in olive oil intake was associated with 11% lower breast cancer odds (OR 0.89, P = 0.03).
- Effect
- Benefit
- Dose
- 30 g
- Population
- Women
- Participants
- 2,588
ObservationalDietary fat, olive oil intake and breast cancer risk1994n=762
In 762 Spanish breast cancer cases vs 988 controls, highest vs lowest olive oil intake quartile was associated with 34% lower breast cancer risk (OR 0.66) with a significant trend.
- Effect
- Benefit
- Population
- Women
- Participants
- 762
- Ages
- 18–75
Green TeaView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Research on green tea and breast cancer risk gives mixed results.
- Some studies find no overall link, but certain groups like Asian-American women may have a lower risk when they drink green tea.
- This might depend on genetic differences or whether a woman is before or after menopause.
- Drinking green tea daily may help reduce the chance of breast cancer coming back in women with early stages of the disease, especially in Asian populations.
- The US Food and Drug Administration says green tea may reduce breast cancer risk but there is limited evidence for this claim.
Browse 12 studies·5 meta-analyses
MetaGreen tea (Camellia sinensis) for the prevention of cancer2020n=1,795
A Cochrane review found very low-certainty evidence that green tea may reduce some cancer risks, with no clear effect on overall cancer incidence.
- Effect
- Benefit
- Participants
- 1,795
MetaGreen Tea Consumption and Risk of Breast Cancer and Recurrence-A Systematic Review and Meta-Analysis of Observational Studies2018n=163,810
A systematic review found higher green tea consumption associated with lower breast cancer incidence and recurrence risk in observational studies.
- Effect
- Benefit
- Population
- Women
- Participants
- 163,810
MetaThe association between green tea consumption and breast cancer risk: A systematic review and meta-analysis2018
A meta-analysis of 14 observational studies found higher green tea consumption associated with lower breast cancer risk, though cohort evidence was weaker.
- Effect
- No Benefit
- Population
- Women
MetaTea consumption and the risk of five major cancers: a dose-response meta-analysis of prospective studies2014n=702
A dose-response meta-analysis of prospective studies found higher tea consumption associated with lower breast, colorectal, and liver cancer risk, but not prostate or stomach cancer.
- Effect
- No Benefit
- Participants
- 702
MetaGreen tea consumption and breast cancer risk or recurrence: a meta-analysis2010
A meta-analysis of observational studies found no clear association between green tea consumption and breast cancer incidence or recurrence.
- Effect
- Benefit
ObservationalGreen tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore2005
In a case-control study of Chinese women, green tea intake combined with low-activity ACE genotype was associated with lower breast cancer risk.
- Effect
- Benefit
- Population
- Women
MetaThe effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis2005
A meta-analysis found higher green tea consumption associated with lower breast cancer incidence in cohort studies but not in case-control studies.
- Effect
- Benefit
- Population
- Women
Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan2004n=409
In a pooled analysis of 35,004 Japanese women (222 breast cancers), green tea intake was not associated with lower breast cancer risk (RR 0.84 for ≥5 vs <1 cup/day).
- Effect
- No Benefit
- Population
- Women
- Participants
- 409
- Ages
- 40–64
ObservationalGreen tea and risk of breast cancer in Asian Americans2003
In a case-control study of Asian-American women, higher green tea consumption was associated with lower breast cancer risk versus lower intake.
- Effect
- Benefit
- Population
- Women
ObservationalTea intake, COMT genotype, and breast cancer in Asian-American women2003
In a case-control study of Asian-American women, green tea intake was inversely associated with breast cancer risk, with effect modification by COMT genotype.
- Effect
- Benefit
- Population
- Women
ObservationalRegular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan2001n=133
In a follow-up study of 1160 Japanese breast cancer patients, regular green tea consumption before diagnosis was associated with lower recurrence risk.
- Effect
- Benefit
- Population
- Cancer patients
- Participants
- 133
ObservationalInfluence of drinking green tea on breast cancer malignancy among Japanese patients1998n=472
In a study of 472 Japanese breast cancer patients, higher pre-diagnosis green tea consumption was associated with less lymph node involvement at surgery.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 472
CalciumView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Taking calcium, whether through diet or supplements, does not seem to prevent breast cancer overall.
- Some studies suggest that eating foods with more calcium might slightly lower breast cancer risk, especially after menopause, but calcium supplements do not show the same benefit.
- Research including a large clinical trial found that taking calcium and vitamin D together for several years did not reduce breast cancer risk in postmenopausal women.
- More research is needed, but right now calcium is not considered helpful for preventing breast cancer.
Browse 9 studies·2 meta-analyses
MetaAssociation between calcium intake and risk of breast cancer: An updated systematic review and dose-response meta-analysis of cohort studies2023n=6
A dose-response meta-analysis of 7 cohorts (1.58 million participants) found each 350 mg/day higher dietary calcium linked to 6% lower breast cancer risk; total calcium showed weaker associations.
- Effect
- Benefit
- Dose
- 350 mg/day
- Participants
- 6
ObservationalDairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies2021n=37
A pooled analysis of >1 million women found no clear overall link between dairy, dietary, or total calcium and breast cancer, though yogurt and cottage/ricotta cheese showed subtype-specific patterns.
- Effect
- No Benefit
- Dose
- 300 mg/day
- Population
- Women
- Participants
- 37
- Ages
- 8–20
ObservationalDietary calcium, vitamin D, and breast cancer risk in women: findings from the SUN cohort2021n=10,812
In 10,812 women followed 10.7 years, moderate total calcium intake (~1400 mg/day) was associated with lower breast cancer risk, especially postmenopausally; vitamin D intake showed no association.
- Effect
- Benefit
- Dose
- 1400 mg/day
- Population
- Postmenopausal women
- Participants
- 10,812
RCTEffect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial2021
A 2-year cluster RCT in 7,195 aged-care residents found extra dairy (562 mg/day calcium) reduced hip fractures (HR 0.43) and falls vs usual menus providing ~700 mg/day calcium.
- Dose
- 600 mg/day
- Population
- Older adults
- Avg age
- ~86
MetaCalcium intake and breast cancer risk: meta-analysis of prospective cohort studies2016n=895
A meta-analysis of 11 cohorts (872,895 participants) found high vs low calcium intake associated with 8% lower breast cancer risk overall and stronger protection for premenopausal disease.
- Effect
- Benefit
- Dose
- 300 mg/day
- Population
- Postmenopausal women
- Participants
- 895
RCTCalcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative2013n=36
In WHI (36,282 postmenopausal women), 7 years of 1000 mg calcium plus 400 IU vitamin D did not reduce hip fracture, colorectal cancer, breast cancer, CVD, or mortality; post-intervention follow-up was similar.
- Effect
- No Benefit
- Dose
- 600 IU/day
- Population
- Postmenopausal women
- Participants
- 36
Systematic reviewVitamin D and calcium: a systematic review of health outcomes2009
An AHRQ systematic review commissioned for DRI revision summarized evidence linking vitamin D, calcium, and combined intake to diverse health outcomes without drawing single definitive conclusions.
- Effect
- Benefit
- Population
- Postmenopausal women
RCTCalcium plus vitamin D supplementation and the risk of breast cancer2007n=36
In WHI (36,282 postmenopausal women), 1000 mg calcium plus 400 IU vitamin D daily for ~7 years did not reduce invasive breast cancer incidence vs placebo.
- Effect
- No Benefit
- Dose
- 400 IU/day
- Population
- Postmenopausal women
- Participants
- 36
ObservationalIntakes of calcium and vitamin D and breast cancer risk in women2007n=31,487
In 31,487 women followed ~10 years, higher calcium and vitamin D intake were modestly associated with lower premenopausal breast cancer risk but not clearly in postmenopausal women.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 31,487
FlaxseedView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is not clear if eating flaxseed reduces the risk of developing breast cancer or affects how the disease progresses.
- One small study in women newly diagnosed with breast cancer showed that eating a muffin with 25 grams of ground flaxseed daily for about 40 days lowered markers that indicate tumor growth compared to the start of the study, but not compared to a placebo muffin without flaxseed.
- The study did not look at longer-term outcomes.
- Many studies have found that people who eat more foods containing lignans, like flaxseed, or have higher levels of these compounds in their blood tend to have a lower risk of getting breast cancer, especially in women after menopause.
- However, it is still uncertain if flaxseed lignan alone is responsible for this benefit.
- Some early research suggests flaxseed may help slow tumor growth by influencing hormone activity, but more research is needed to be sure.
Browse 9 studies
ObservationalDietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women2008n=137
Among 51,823 postmenopausal women in the Swedish Mammography Cohort, highest-quartile dietary lignan intake was associated with a 17% lower overall breast cancer risk, particularly among hormone therapy users.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 137
- Ages
- 70+
ObservationalDietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women2008n=45,448
In a Swedish cohort of 45,448 women with 1,014 breast cancers, dietary coumestrol—but not lignans or isoflavonoids—was inversely associated with ER-/PR- breast tumors.
- Effect
- No Benefit
- Population
- Postmenopausal women
- Participants
- 45,448
ObservationalEnterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study2008
In a Swedish nested case-control of 366 breast cancer cases and 733 controls, plasma enterolactone above the median was associated with lower breast cancer risk, especially for ERalpha-positive and ERbeta-negative tumors.
- Effect
- Benefit
ObservationalDietary flavonoid intake and breast cancer risk among women on Long Island2007n=1
In a Long Island case-control study of 1,434 breast cancer cases and 1,440 controls, higher flavonoid intake—especially in postmenopausal women—was associated with lower breast cancer risk.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 1
ObservationalDietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status2007
In a French cohort of 58,049 postmenopausal women, dietary lignan intake showed no clear overall association with breast cancer risk, with inconsistent patterns across ER/PR subtypes.
- Population
- Postmenopausal women
ObservationalDietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada)2007n=3
In an Ontario case-control study of 3,063 breast cancer cases and 3,430 controls (ages 25–74), highest-quintile lignan intake was associated with 19% lower breast cancer odds overall, with stronger protection in overweight women.
- Effect
- Benefit
- Population
- Women
- Participants
- 3
- Ages
- 25–74
ObservationalPlasma phytoestrogens and subsequent breast cancer risk2007n=383
In a Dutch nested case-control of 383 breast cancer cases matched to 383 controls, highest-tertile plasma genistein was associated with 32% lower breast cancer risk; lignan levels showed no association.
- Effect
- No Benefit
- Population
- Postmenopausal women
- Participants
- 383
- Ages
- 52–59
ObservationalAdolescent dietary phytoestrogen intake and breast cancer risk (Canada)2006n=3
In an Ontario case-control of 3,024 breast cancer cases and 3,420 controls (ages 25–74), higher adolescent phytoestrogen intake (isoflavones and lignans) was associated with reduced adult breast cancer risk.
- Effect
- Benefit
- Population
- Women
- Participants
- 3
- Ages
- 25–74
RCTDietary flaxseed alters tumor biological markers in postmenopausal breast cancer2005n=19
In an RCT of 19 postmenopausal women with newly diagnosed breast cancer, 25 g/day flaxseed in muffins for ~32 days before surgery reduced tumor cell proliferation (Ki-67) versus placebo muffins.
- Effect
- Benefit
- Duration
- 32–39 days
- Dose
- 25 g/day
- Population
- Postmenopausal women
- Participants
- 19
Vitamin AView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Eating more vitamin A from food and supplements may be linked to a lower chance of getting breast cancer.
- People who consume the most vitamin A have about a 16% lower risk compared to those who consume the least.
- It is still unknown if taking vitamin A supplements alone provides this benefit.
Browse 3 studies·2 meta-analyses
MetaDietary Vitamin A Intake and Circulating Vitamin A Concentrations and the Risk of Three Common Cancers in Women: A Meta-Analysis2022
A meta-analysis of 49 studies found higher dietary vitamin A intake was associated with lower breast, ovarian, and cervical cancer risk in women (pooled OR 0.83 for diet/supplements), but circulating vitamin A showed no significant association.
- Effect
- Benefit
- Population
- Women
MetaRetinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression2011
A meta-analysis of 51 studies found total vitamin A intake reduced breast cancer risk by 17% (pooled OR 0.83), though retinol and vitamin E associations became nonsignificant in cohort-only subgroup analyses.
- Effect
- Benefit
ObservationalDietary carotenoids and vitamins A, C, and E and risk of breast cancer1999n=83,234
A prospective cohort of 83,234 women in the Nurses' Health Study found higher α-carotene, β-carotene, and vitamin C intake were inversely associated with premenopausal breast cancer risk, especially with family history.
- Effect
- Benefit
- Dose
- 15 g/day
- Population
- Postmenopausal women
- Participants
- 83,234
- Ages
- 33–60
MelatoninView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Research on melatonin for sleep problems in women with breast cancer has been mixed, but a review combining results from several studies found that melatonin can moderately improve sleep quality.
- This suggests that melatonin may help relieve sleep disturbances related to cancer treatments, although more research is still needed.
Browse 1 study·1 meta-analysis
MetaEffects of Melatonin Supplementation on Sleep Quality in Breast Cancer Patients: A Systematic Review and Meta-Analysis2023
A meta-analysis of 5 RCTs found melatonin supplementation moderately improved sleep quality in breast cancer patients (Hedges' g −0.79, p<0.001) during treatment.
- Effect
- Benefit
- Population
- Breast cancer patients
MethionineView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is not clear if eating more methionine-rich foods lowers the risk of breast cancer.
- Some studies suggest a small reduction in risk, especially for women after menopause, but newer research with more participants did not find a clear link.
- More research is needed.
Browse 2 studies·2 meta-analyses
MetaThe association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis2023n=10
A meta-analysis of 21 observational studies found little evidence that dietary methionine or betaine intake affects breast cancer risk; choline showed an inverse association only in case-control studies.
- Effect
- No Benefit
- Participants
- 10
MetaAssociation of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis2013
A dose-response meta-analysis found higher serum pyridoxal 5'-phosphate and dietary methionine intake were inversely associated with breast cancer risk, especially among postmenopausal women.
- Effect
- Benefit
- Dose
- 1 g/day
- Population
- Postmenopausal women
ReishiView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- In a small study, breast cancer patients who took reishi mushroom powder three times daily for 4 weeks had less cancer-related fatigue than those taking a placebo, but it is unclear if this improvement is significant in everyday life.
Browse 1 study
RCTSpore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial2012
In breast cancer patients on endocrine therapy over 4 weeks, Ganoderma lucidum spore powder 3 g/day reduced cancer-related fatigue versus control in this pilot trial.
- Effect
- Benefit
- Duration
- 4 weeks
- Dose
- 3000 mg/day
- Population
- Patients with breast cancer
- Ages
- 18+
ResveratrolView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Resveratrol has insufficient evidence for Breast cancer.
Browse 1 study
RCTTrans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer2012
In women at increased breast cancer risk over 12 weeks, trans-resveratrol altered mammary promoter methylation patterns, suggesting possible chemopreventive biological activity.
- Effect
- Benefit
- Duration
- 12 weeks
- Dose
- 50 mg/day
- Population
- Women
Vitamin DView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- The role of vitamin D in preventing breast cancer is uncertain.
- Some studies have found that women with higher vitamin D levels or intake might have a lower risk of breast cancer, especially if they are younger (premenopausal).
- However, other large studies show no clear benefit.
- Clinical trials mostly show that taking vitamin D with calcium does not significantly reduce breast cancer risk in older women, although some analyses suggest it might reduce early breast cancers by about 18% over many years.
- The doses studied usually range from 400 to 1000 IU daily.
- Vitamin D may help prevent certain types of breast cancer and works by slowing cancer cell growth in lab studies.
- Researchers believe that vitamin D might be more helpful for some breast cancer types and in women with low vitamin D levels at the start of treatment, but more large studies are needed to know for sure how much vitamin D to take, when to start, and who will benefit the most.
Browse 11 studies·2 meta-analyses
ObservationalVitamin D concentrations and breast cancer incidence among Black/African American and non-Black Hispanic/Latina women2022n=1,545
In 1,960 Sister Study women, circulating 25(OH)D >20 ng/mL was associated with lower breast cancer risk (HR 0.79), strongest among Hispanic/Latina women (HR 0.52).
- Effect
- Benefit
- Population
- Women
- Participants
- 1,545
ObservationalVitamin D Supplement Use and Risk of Breast Cancer by Race-Ethnicity2022n=50,884
In 50,884 women followed ~10.5 years, recent vitamin D supplement use ≥1/month was inversely associated with breast cancer (HR 0.88), especially ductal carcinoma in situ.
- Effect
- Benefit
- Population
- Women
- Participants
- 50,884
- Ages
- 35–74
RCTA Randomized Trial of Calcium Plus Vitamin D Supplementation and Risk of Ductal Carcinoma In Situ of the Breast2021n=36,282
In 36,282 postmenopausal women given 400 IU/day vitamin D plus 1000 mg calcium for ~20 years, supplementation reduced ductal carcinoma in situ risk (HR 0.82).
- Effect
- Benefit
- Dose
- 400 IU/day
- Population
- Postmenopausal women
- Participants
- 36,282
- Ages
- 50–79
RCTCalcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative2013n=36
In WHI (36,282 postmenopausal women), 7 years of 1000 mg calcium plus 400 IU vitamin D did not reduce hip fracture, colorectal cancer, breast cancer, CVD, or mortality; post-intervention follow-up was similar.
- Effect
- No Benefit
- Dose
- 600 IU/day
- Population
- Postmenopausal women
- Participants
- 36
MetaVitamin D supplementation and breast cancer prevention: a systematic review and meta-analysis of randomized clinical trials2013n=5,372
A meta-analysis of 2 RCTs (5,372 postmenopausal women) found vitamin D supplementation not associated with reduced breast cancer risk (RR 1.11).
- Effect
- No Benefit
- Population
- Postmenopausal women
- Participants
- 5,372
MetaMeta-analysis of vitamin D, calcium and the prevention of breast cancer2010
A meta-analysis found higher vitamin D intake (RR 0.91) and circulating 25(OH)D (OR 0.55) associated with lower breast cancer risk; calcium also showed benefit.
- Effect
- Benefit
ObservationalAssociation between plasma 25-hydroxyvitamin D and breast cancer risk2009n=2,101
In 1,026 breast cancer cases and 1,075 controls, plasma 25(OH)D ≥40 ng/mL was associated with lower breast cancer risk versus <13 ng/mL in a Long Island case-control study.
- Effect
- Benefit
- Population
- Women
- Participants
- 2,101
Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer2009n=60
In 60 postmenopausal women starting letrozole, 50,000 IU/week vitamin D for 12 weeks safely raised 25(OH)D and reduced disability from AI-induced joint pain.
- Effect
- Benefit
- Duration
- 12 weeks
- Dose
- 50000 IU/day
- Population
- Women
- Participants
- 60
RCTCalcium plus vitamin D supplementation and the risk of breast cancer2007n=36
In WHI (36,282 postmenopausal women), 1000 mg calcium plus 400 IU vitamin D daily for ~7 years did not reduce invasive breast cancer incidence vs placebo.
- Effect
- No Benefit
- Dose
- 400 IU/day
- Population
- Postmenopausal women
- Participants
- 36
ObservationalIntakes of calcium and vitamin D and breast cancer risk in women2007n=31,487
In 31,487 women followed ~10 years, higher calcium and vitamin D intake were modestly associated with lower premenopausal breast cancer risk but not clearly in postmenopausal women.
- Effect
- Benefit
- Population
- Postmenopausal women
- Participants
- 31,487
ObservationalVitamin D and prevention of breast cancer: pooled analysis2007n=1,760
A pooled analysis of 1,760 individuals found serum 25(OH)D ~52 ng/mL associated with 50% lower breast cancer risk versus <13 ng/mL in observational data.
- Effect
- Benefit
- Dose
- 4000 IU/day
- Population
- Adults
- Participants
- 1,760
American GinsengView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is uncertain if American ginseng improves survival in breast cancer.
- A large study in China found that patients using ginseng, including American and Panax ginseng, had better quality of life and lower chances of death or cancer recurrence.
- However those who took ginseng were also more likely to have been treated with the breast cancer drug tamoxifen so clear conclusions cannot be made.
Browse 1 study
ObservationalAssociation of ginseng use with survival and quality of life among breast cancer patients2006
In 1,455 Shanghai breast cancer patients followed ~6 years, regular ginseng use before diagnosis was linked to 29–30% lower mortality and recurrence risk; post-diagnosis use correlated with better quality of life.
- Effect
- Benefit
- Population
- Breast cancer patients
Flaxseed OilView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Research shows that women with higher levels of a healthy fat called alpha-linolenic acid (ALA), found in flaxseed oil, in the fat tissue of their breasts have a lower chance of developing breast cancer.
- Since the fat in breast tissue reflects what a person has eaten over time, scientists think that eating more ALA might help protect against breast cancer.
- Still, it is not clear if eating flaxseed oil itself lowers breast cancer risk, and more studies are needed to find out.
Browse 2 studies
ObservationalLow alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer2000n=123
In 123 breast cancer cases versus 59 benign controls in France, lower adipose breast tissue alpha-linolenic acid was associated with increased invasive breast carcinoma risk in adjusted analyses.
- Effect
- Benefit
- Population
- Women
- Participants
- 123
Observationalalpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer1994n=121
In 121 localized breast cancer patients followed ~31 months, low adipose alpha-linolenic acid predicted early visceral metastasis along with large tumor size in multivariate analysis.
- Effect
- Benefit
- Population
- Cancer patients
- Participants
- 121
Gamma-Linolenic AcidView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- In a small study of women with hormone-sensitive breast cancer, taking gamma-linolenic acid (GLA) together with the standard breast cancer drug tamoxifen helped tumors respond faster compared to tamoxifen alone.
- Patients took GLA capsules daily along with tamoxifen for 6 weeks.
- The treatment was safe and showed signs of making tamoxifen work better by affecting estrogen receptors in the tumors.
Browse 1 study
Controlled trialGamma linolenic acid with tamoxifen as primary therapy in breast cancer2000n=47
In 38 breast cancer patients on tamoxifen, adding 2.8 g/day GLA produced faster clinical responses and greater tumor marker improvements than tamoxifen alone in this small controlled trial.
- Effect
- Benefit
- Dose
- 2.8 g/day
- Population
- Women
- Participants
- 47
GarlicView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Early research on garlic for breast cancer risk is limited.
- A case-control study in Puerto Rico examining the association between onion and garlic intake and breast cancer risk in women.
- More studies are needed before any benefit can be considered reliable.
Browse 2 studies
ObservationalOnion and Garlic Intake and Breast Cancer, a Case-Control Study in Puerto Rico2020n=346
In a Puerto Rican case-control study of 314 breast cancer cases and 346 controls (ages 30–79), higher onion and garlic intake—including sofrito—was associated with lower breast cancer odds.
- Effect
- Benefit
- Population
- Women
- Participants
- 346
- Ages
- 30–79
ObservationalAllium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence1995n=1,713
In the Netherlands Cohort Study of 120,852 adults (ages 55–69), onion, leek, and garlic supplement intake showed no clear association with female breast cancer after 3.3 years of follow-up.
- Effect
- No Benefit
- Population
- Adults
- Participants
- 1,713
- Ages
- 55–69
LuteinView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Research from Korea suggests that people who eat more foods containing lutein and zeaxanthin may have a lower risk of breast cancer.
- This effect appears most noticeable in women after menopause and in those with hormone receptor–negative breast cancer.
Browse 1 study
ObservationalAssociation between dietary carotenoid intake and breast cancer risk: a case-control study among Korean women2024
A Korean case-control study found higher β-carotene and lutein/zeaxanthin intake associated with lower breast cancer risk, especially in ER+ subtypes.
- Effect
- Benefit
- Population
- Women
Vitamin B9 (Folate)View supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is unclear if taking folic acid affects the risk of breast cancer.
- Some older studies found no effect from folic acid alone.
- But in some women, especially those who also consume higher amounts of certain other nutrients like vitamin B12 or B6, getting enough folate may lower breast cancer risk.
- More recent research shows that taking moderate amounts of folic acid (between 150 and 400 micrograms daily) may lower the chance of breast cancer, especially for women who drink alcohol regularly.
- Taking more than 400 micrograms daily doesn’t seem to provide extra protection and might even increase risk if early cancer changes are already present.
- This suggests that getting the right amount of folate is important, and both too little and too much may affect breast cancer risk.
Browse 4 studies·3 meta-analyses
MetaHigher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis2014n=5,924
A meta-analysis of 5924 participants found that 153–400 μg increased dietary folate intake reduced breast cancer risk for women with higher alcohol intake level, but not for those with lower alcohol intake.
- Effect
- Benefit
- Dose
- 153–400 μg
- Population
- Women
- Participants
- 5,924
MetaFolate and risk of breast cancer: a meta-analysis2007n=306,209
A meta-analysis of 306209 participants found that high blood folate levels versus low levels were not statistically significantly associated with the risk of breast cancer in prospective studies (OR = 0.81, 95% CI = 0.59 to 1.10 [three studies]) or in case-control studies (OR = 0.41, 95% CI = 0.15 to 1.10 [two studies]).
- Effect
- No Benefit
- Population
- Women
- Participants
- 306,209
MetaMeta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk2006
A meta-analysis of 13 studies found that we found no difference in breast cancer risk between MTHFR 677 TT homozygotes and CC homozygotes (OR = 1.05, 95% CI = 0.88 to 1.25), and there was no evidence of an interaction between folate intake and MTHFR genotype on breast cancer risk.
- Effect
- No Benefit
ObservationalDietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study2001n=1,321
An observational study of 1321 women found that unconditional logistic regression models were used to calculate odds ratios (ORs) and their 95% confidence intervals (95% CIs) after adjusting for potential confounding factors.
- Effect
- Benefit
- Population
- Women
- Participants
- 1,321
- Ages
- 25–64
Vitamin EView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- Taking vitamin E supplements does not lower the chance of developing breast cancer.
- Some studies suggest that having higher vitamin E levels in the blood might reduce breast cancer risk.
- However, eating more vitamin E or taking supplements does not seem to prevent breast cancer.
- Large studies show that women taking vitamin E supplements daily or every other day for several years did not have a lower risk of getting breast cancer.
- Oral vitamin E does not reduce hot flashes in females who have had breast cancer.
Browse 9 studies·2 meta-analyses
MetaConsumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis2023
A systematic review/meta-analysis of 22 studies found no significant link between dietary or supplemental vitamin E and breast cancer risk; intake was inversely associated with recurrence only.
- Effect
- No Benefit
RCTVitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial2009n=8,171
In WACS (8,171 women), 600 IU vitamin E every other day for 9.4 years did not reduce total cancer incidence (RR 0.93) or cancer mortality versus placebo.
- Effect
- No Benefit
- Dose
- 600 IU/day
- Population
- Women
- Participants
- 8,171
- Ages
- 45+
MetaThe role of vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials2007n=67,025
A meta-analysis of 12 RCTs (167,025 participants) found vitamin E did not reduce total mortality or overall cancer but lowered prostate cancer incidence (RR 0.85).
- Effect
- No Benefit
- Population
- Adults
- Participants
- 67,025
RCTEffects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial2005n=9,541
In HOPE-TOO (9,541 patients, ~7 years), 400 IU/day vitamin E did not prevent cancer or major cardiovascular events and increased heart failure risk (RR 1.13).
- Effect
- No Benefit
- Dose
- 400 IU/day
- Population
- Heart failure patients
- Participants
- 9,541
- Ages
- 55+
RCTVitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study2005
In the Women's Health Study (39,876 women, 600 IU EOD for 10.1 years), vitamin E did not reduce major cardiovascular events or total cancer but lowered cardiovascular mortality (RR 0.76).
- Effect
- No Benefit
- Dose
- 600 IU/day
- Population
- Women
- Ages
- 45+
ObservationalRelationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer2001
An observational study of serum alpha-tocopherol, carotenoids, and retinol found no consistent protective association with breast cancer risk.
- Effect
- No Benefit
RCTProspective evaluation of vitamin E for hot flashes in breast cancer survivors1998n=120
In an RCT of 120 breast cancer survivors, 800 IU/day vitamin E for 4 weeks reduced hot flashes by about one per day versus placebo—a statistically significant but clinically marginal effect.
- Effect
- Benefit
- Duration
- 4 weeks
- Dose
- 800 IU/day
- Population
- Women
- Participants
- 120
ObservationalA prospective study of the intake of vitamins C, E, and A and the risk of breast cancer1993n=1,439
In a prospective cohort of 89,494 women, higher vitamin E intake was not associated with lower breast cancer risk (RR 0.99 for highest vs lowest quintile).
- Effect
- No Benefit
- Population
- Women
- Participants
- 1,439
- Ages
- 34–59
ObservationalDietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort study1993n=56,837
In a cohort of 56,837 Canadian women, vitamin E intake was not associated with altered breast cancer risk after adjustment for other dietary factors.
- Effect
- No Benefit
- Population
- Women
- Participants
- 56,837
Vitamin KView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is not clear if eating vitamin K2 lowers the chance of getting breast cancer.
- Studies show that eating more vitamin K2 or vitamin K1 is not linked to a lower risk of breast cancer in women before or after menopause.
Browse 1 study
ObservationalDietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)2010n=24,340
In an observational study of 24,340 participants, multivariate-adjusted hazard ratios (HRs) and 95% CIs were estimated by using Cox proportional hazards models.
- Effect
- Benefit
- Population
- Cancer patients
- Participants
- 24,340
- Ages
- 35–64
ZeaxanthinView supplement →
Reconsider purchase·★★★★★
How we scored this▸
- It is not clear if taking zeaxanthin by mouth prevents breast cancer.
- Studies show that higher levels of lutein and zeaxanthin in the blood are linked to a lower risk of breast cancer.
Browse 1 study
ObservationalRelationship of serum α-tocopherol, carotenoids and retinol with the risk of breast cancer2001
An observational study examined whether serum α-tocopherol, carotenoids, and retinol levels relate to breast cancer risk.
Black TeaView supplement →
Do not purchase·★★★★★
How we scored this▸
- Studies show that drinking black tea does not lower the risk of breast cancer.
- People who drink black tea have about the same risk as those who don’t.
Browse 2 studies·1 meta-analysis
MetaMeta-analysis of black tea consumption and breast cancer risk: update 20132014
A meta-analysis through 2013 found no overall association between black tea consumption and breast cancer risk (OR 0.97); cohort and case-control subgroups also showed no significant benefit.
- Effect
- No Benefit
ObservationalCoffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women2002n=59,036
In 59,036 Swedish women followed 508,267 person-years, coffee, tea, and caffeine intake were not associated with breast cancer incidence across consumption levels.
- Effect
- No Benefit
- Population
- Women
- Participants
- 59,036
- Ages
- 40–76
MultivitaminView supplement →
Do not purchase·★★★★★
How we scored this▸
- Research hasn’t shown that taking a daily multivitamin helps prevent breast cancer.
- Studies following people for up to 10 years found no lower risk in those who took multivitamins.
Browse 2 studies·1 meta-analysis
GuideVitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement2022
A USPSTF evidence review found insufficient evidence that multivitamin or mineral supplementation prevents cardiovascular disease or cancer in healthy adults.
- Effect
- No Benefit
- Population
- Adults
MetaMultivitamin supplement use and risk of breast cancer: a meta-analysis2011n=355,080
A meta-analysis of 355,080 women found no significant association between multivitamin use and breast cancer risk over 3–10 years of follow-up.
- Effect
- No Benefit
- Population
- Women
- Participants
- 355,080
- Ages
- 3–10
Oleic AcidView supplement →
Do not purchase·★★★★★
How we scored this▸
- Studies have found no clear link between eating oleic acid or other dietary fats and breast cancer risk.
- The effects of oleic acid supplements on breast cancer are not known.
Browse 1 study·1 meta-analysis
MetaDietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies2016
A meta-analysis found higher total fat intake associated with 10% higher breast cancer risk (RR 1.10), but no significant associations for MUFA, PUFA, or oleic acid individually.
- Effect
- No Benefit
Panax GinsengView supplement →
Do not purchase·★★★★★
How we scored this▸
- It is not clear if taking Panax ginseng helps people with breast cancer.
- Some studies suggest people who take ginseng regularly have better quality of life and lower chances of dying or cancer coming back, but these people also were more likely to take tamoxifen, a cancer drug.
- Another small study found that taking 1 gram daily of Panax ginseng during chemotherapy improved social and emotional well-being but did not help physical health.
Browse 2 studies
RCTEffects of Panax Ginseng on Health-Related Quality of Life in Patients with Non-Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Ginseng for HRQOL in Breast Cancer2023n=40
An RCT in 40 women with early breast cancer found 1 g/day ginseng during chemotherapy did not prevent declines in health-related quality of life versus placebo.
- Effect
- No Benefit
- Dose
- 1 g/day
- Population
- Women
- Participants
- 40
ObservationalAssociation of ginseng use with survival and quality of life among breast cancer patients2006
In 1,455 Shanghai breast cancer patients followed ~6 years, regular ginseng use before diagnosis was linked to 29–30% lower mortality and recurrence risk; post-diagnosis use correlated with better quality of life.
- Effect
- Benefit
- Population
- Breast cancer patients
Vitamin CView supplement →
Do not purchase·★★★★★
How we scored this▸
- Vitamin C has no meaningful benefit for Breast cancer.
Browse 2 studies
ObservationalVitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C2016n=57,403
In 57,403 postmenopausal women, vitamin C supplement use was associated with higher breast cancer risk among those with high dietary vitamin C (HR 1.32).
- Effect
- No Benefit
- Population
- Postmenopausal women
- Participants
- 57,403
ObservationalSerum antioxidant nutrients, vitamin A, and mortality in U.S. Adults2013n=16,008
In 16,008 US adults followed 14 years, higher serum vitamin C was associated with lower cancer and all-cause mortality; vitamin A and E showed U-shaped mortality associations.
- Population
- Adults
- Participants
- 16,008
Evidence visualised
Same ratings as above, aggregated so you can see coverage and imbalance.
| Supplement | DEX | Studies | Meta-analyses | Share |
|---|---|---|---|---|
| Nattokinase | ★★★★★68% | 18 | 4 | 17% |
| Green Tea | ★★★★★56% | 12 | 5 | 12% |
| Vitamin D | ★★★★★44% | 11 | 2 | 11% |
| Calcium | ★★★★★52% | 9 | 2 | 9% |
| Flaxseed | ★★★★★52% | 9 | 0 | 9% |
| Vitamin E | ★★★★★40% | 9 | 2 | 9% |
| Olive Oil | ★★★★★68% | 5 | 2 | 5% |
| Vitamin B9 (Folate) | ★★★★★40% | 4 | 3 | 4% |
| Vitamin A | ★★★★★52% | 3 | 2 | 3% |
| Black Tea | ★★★★★36% | 2 | 1 | 2% |
| Flaxseed Oil | ★★★★★40% | 2 | 0 | 2% |
| Garlic | ★★★★★40% | 2 | 0 | 2% |
| Methionine | ★★★★★48% | 2 | 2 | 2% |
| Multivitamin | ★★★★★36% | 2 | 1 | 2% |
| Panax Ginseng | ★★★★★32% | 2 | 0 | 2% |
| Vitamin C | ★★★★★28% | 2 | 0 | 2% |
| American Ginseng | ★★★★★40% | 1 | 0 | <1% |
| Gamma-Linolenic Acid | ★★★★★40% | 1 | 0 | <1% |
| Lutein | ★★★★★40% | 1 | 0 | <1% |
| Melatonin | ★★★★★48% | 1 | 1 | <1% |
| Oleic Acid | ★★★★★36% | 1 | 1 | <1% |
| Reishi | ★★★★★44% | 1 | 0 | <1% |
| Resveratrol | ★★★★★44% | 1 | 0 | <1% |
| Vitamin K | ★★★★★40% | 1 | 0 | <1% |
| Zeaxanthin | ★★★★★40% | 1 | 0 | <1% |