Bipolar disorder
Supplements studied for bipolar disorder.
Overview
Eleven supplements are indexed for bipolar disorder across 19 studies, mostly with low ratings.
Flaxseed Oil (DEX Score 32; very low effect size, low evidence, medium trust) did not improve mania or depression in children and teens over 16 weeks. Melatonin (DEX Score 40; very low effect size, high evidence, medium trust) may aid sleep in early research but larger trials show no overall symptom benefit; it may worsen depression in some people. Inositol (DEX Score 48; low effect size, medium evidence, medium trust) combined with omega-3s may reduce mood symptoms in children more than either alone.
Folate (DEX Score 52; low effect size, high evidence, medium trust) effects vary by co-medication—no added benefit with lithium, but possible mania reduction with valproate in one study. See the heatmap and evidence reviews below for all eleven supplements.
Effect graph
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Relevant supplements heatmap
Relevant supplements sorted by DEX Score.
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SupplementDEX Database
11 supplements for and rated at least stars. All purchase bands. No minimum star filter.
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Evidence visualised
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Visual summaries of supplement evidence ranked by condition.
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