Diabetic Neuropathy
Supplements studied for diabetic neuropathy.
Overview
Alpha-Lipoic Acid (DEX Score 68; medium effect size, very high evidence, medium trust; 31 studies) has the strongest support: 600–1800 mg daily may relieve burning, pain, numbness, and tingling within weeks, though nerve function tests often do not improve. Acetyl-L-Carnitine (DEX Score 72; medium effect size, high evidence, very high trust) at 2–3 g daily may reduce pain and improve sensation, especially in newer or poorly controlled type-2-diabetes.
Coenzyme Q10 (DEX Score 64; medium effect size, medium evidence, high trust) and Gamma-Linolenic Acid (DEX Score 56; medium effect size, low evidence, medium trust) also show medium evidence in small trials for pain relief and nerve function when blood sugar is controlled. Inositol (DEX Score 36; very low effect size, medium evidence, medium trust) did not help in early research. The heatmap and evidence reviews below detail all 13 supplements.
Effect graph
Subscribe to access all content
Interactive visualisations of ranked conditions and clinical benefit with purchase guidance.
Already a subscriber? Sign in
Relevant supplements heatmap
Relevant supplements sorted by DEX Score.
Subscribe to access all content
See effect size, evidence strength, and trust at a glance for every condition.
Already a subscriber? Sign in
SupplementDEX Database
14 supplements for , and rated at least stars. All purchase bands. No minimum star filter.
Subscribe to access all content
Read this and 2,600+ other evidence reviews on our practitioner plan.
Already a subscriber? Sign in
Evidence visualised
Subscribe to view condition evidence
Visual summaries of supplement evidence ranked by condition.
Already a subscriber? Sign in