Graft-versus-host disease

Overview

Only one supplement—Vitamin A—is indexed for graft-versus-host disease, based on a single low-rated study (WA 44; low effect size, low evidence, medium trust; 1 study). That trial found a high pre-transplant vitamin A dose given about a week before stem cell transplant may lower the chance of long-term graft-versus-host disease in young patients with low vitamin A levels.

However, vitamin A did not appear to reduce early or gut-related GVHD in that study. Patients with low vitamin D also received vitamin D supplements during the trial, which limits how much can be attributed to vitamin A alone. Overall evidence is very limited. See the evidence review below.

Effect graph

Relevant supplements

Relevant supplements sorted by DEX Score.

Studies

Find individual evidence reviews for supplements sorted by DEX Score.

Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.