Gout
Supplements studied for gout.
Overview
Four supplements have been studied for gout across eight trials. Vitamin C has the strongest profile (medium effect size, high evidence, high trust, DEX Score 68; 5 studies). Observational data suggest higher daily vitamin C intake may be linked to lower gout risk and slightly lower uric acid in men, but for people who already have gout, short-term supplementation does not appear to reduce uric acid levels.
IP-6 (DEX Score 32), L-Tryptophan (DEX Score 44), and Vitamin B9 (Folate) (DEX Score 36) each have low ratings and only one study each. Early work suggests IP-6 may lower uric acid in asymptomatic hyperuricemia, and a tryptophan-glycine powder may reduce uric acid modestly—though which ingredient drives any effect is unclear. Higher dietary folate may be associated with lower gout risk in low-quality research.
Evidence remains uncertain for treatment of established gout. See the heatmap and evidence reviews below for details.
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SupplementDEX Database
4 supplements for , and rated at least stars. All purchase bands. No minimum star filter.
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