Endometrial cancer

Overview

Endometrial cancer has four reviewed supplements. Green Tea (WA 68; medium effect size, high evidence, high trust) shows the strongest signal: regular intake, usually more than once daily, is linked to about 20% lower endometrial cancer risk in observational research, mostly in Asian cohorts, with risk declining per additional cup.

Black Tea (WA 36; very low effect size, medium evidence, medium trust) did not show protection per extra cup. Nattokinase has insufficient evidence. Flaxseed-related blood markers correlate with lower risk in some studies but do not prove flaxseed itself is protective. See the heatmap and evidence reviews below for all four entries.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Green Tea	★★★★★	Medium
Nattokinase	★★★★★	Low
Black Tea	★★★★★	Very Low / None
Flaxseed	★★★★★	Very Low / None

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Studies

Find individual evidence reviews for supplements sorted by DEX Score.

4 supplements for , and rated at least stars. All purchase bands. No minimum star filter.

Green TeaView supplement →

Consider purchase★★★★★

How we scored this

Effect SizeMediumEvidenceHighTrustHigh

Evidence Review

Drinking green tea regularly, usually more than once a day, is linked to a lower chance of developing endometrial cancer—about 20% less compared to those who rarely or never drink it.
Each extra cup of green tea daily may reduce the risk even more.
These benefits have been seen mostly in studies from Asia.
Black tea does not seem to offer the same protection.

Browse 3 studies2 meta-analyses

MetaGreen tea (Camellia sinensis) for the prevention of cancer2020n=1,795

A Cochrane review found very low-certainty evidence that green tea may reduce some cancer risks, with no clear effect on overall cancer incidence.

Effect: Benefit
Participants: 1,795

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MetaGreen tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis2016

A meta-analysis found green tea associated with 22% lower endometrial cancer risk (RR 0.78 per cup/day increment); black tea showed no significant association (RR 0.99).

Effect: Benefit

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MetaTea consumption and risk of endometrial cancer: a metaanalysis2009

A meta-analysis found higher tea consumption associated with lower endometrial cancer risk, with a 15% risk reduction per 2 cups/day increment.

Effect: Benefit

View on PubMed

NattokinaseView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceHighTrustMedium

Evidence Review

There is not enough evidence to determine if nattokinase has any benefit for endometrial cancer.

Browse 5 studies1 meta-analysis

ObservationalSoy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study2015

In 49,121 Japanese women followed 12.1 years (112 endometrial cancers), soy food and isoflavone intake were not associated with endometrial cancer risk.

Effect: No Benefit
Dose: 25 g/day
Population: Women
Ages: 45–74

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MetaSoy Intake Is Associated With Lower Endometrial Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies2015

A meta-analysis of observational studies found dietary soy intake associated with 19% lower endometrial cancer risk (pooled RR 0.81), strongest for unfermented soy in postmenopausal Asian women.

Effect: Benefit
Population: Postmenopausal women

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RCTEffect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial2013n=224

In 224 postmenopausal women, 154 mg/day isoflavone soy protein for 3 years did not change endometrial thickness or increase endometrial hyperplasia vs milk protein placebo.

Effect: No Benefit
Duration: 3 years
Dose: 154 mg/day
Population: Postmenopausal women
Participants: 224
Ages: 45–92

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ObservationalSoya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study2004

In 832 endometrial cancer cases vs 846 Shanghai controls, higher soy protein and isoflavone intake over 5 years was inversely associated with endometrial cancer risk (P trend 0.01).

Effect: Benefit
Population: Women
Ages: 30–69

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ObservationalAssociation of soy and fiber consumption with the risk of endometrial cancer1997n=511

In 332 endometrial cancer cases vs 511 Hawaii controls, higher soy and fiber intake was inversely associated with endometrial cancer risk after adjusting for fat and energy intake.

Effect: Benefit
Population: Women
Participants: 511

View on PubMed

Black TeaView supplement →

Do not purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceMediumTrustMedium

Evidence Review

Research shows that drinking one extra cup of tea a day, does not appear to lower the risk of endometrial cancer compared to drinking little or no black tea.

Browse 1 study1 meta-analysis

MetaGreen tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis2016

A meta-analysis found green tea associated with 22% lower endometrial cancer risk (RR 0.78 per cup/day increment); black tea showed no significant association (RR 0.99).

Effect: No Benefit

View on PubMed

FlaxseedView supplement →

Do not purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceLowTrustLow

Evidence Review

It is not clear whether eating flaxseed lowers the risk of endometrial cancer.
Some studies suggest that higher levels of flaxseed-related compounds in the body are linked to lower risk, but this does not prove flaxseed itself is protective.

Browse 1 study

ObservationalCirculating enterolactone and risk of endometrial cancer2006

In a nested case-control of 153 endometrial cancer cases and 271 controls across three cohorts, circulating enterolactone showed no association with endometrial cancer risk.

Effect: No Benefit
Population: Postmenopausal women

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 4 supplements for endometrial cancer (10 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Nattokinase	★★★★★52%	5	1	50%
Green Tea	★★★★★68%	3	2	30%
Black Tea	★★★★★36%	1	1	10%
Flaxseed	★★★★★28%	1	0	10%

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Overview

Effect graph

Relevant supplements

Studies

Evidence visualised

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