Inositol
Inositol is studied for PCOS, metabolic, and mood-related outcomes. Effects depend on form (myo-/D-chiro) and dose.
Overview
What is inositol?
Inositol is a sugar alcohol that is produced by the body that was once considered to be an essential B vitamin.
Inositol can improve insulin sensitivity and glycemic control, and may help manage polycystic ovary syndrome (PCOS) and prevent gestational type-2-diabetes. The most commonly supplemented forms of inositol are myo-inositol and D-chiro-inositol, but all forms are interchangeably referred to as inositol.
Dosage
A typical dose is 1-4 grams per day for gestational type-2-diabetes and polycystic ovary syndrome.
Effect graph
Effect heatmap
SupplementDEX Database
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Database Snapshot
Most inositol research is concentrated in a handful of conditions.
- Polycystic ovary syndrome accounts for 25 of 101 studies (25%).
- Depression accounts for 10 of 101 studies (10%).
- Infertility accounts for 8 of 101 studies (8%).
- Sparse coverage remains for Alzheimer's disease, Hashimoto's thyroiditis, Hypothyroidism.
Dietary Sources
Top dietary sources
Food sources
Sources include Beans, Cabbage, Citrus Fruits, Dried Prunes, Lentils, Nuts, Seeds, and Whole Grain Breads.
Safety
Side effects from inositol supplementation are rare, but may include nausea and diarrhea at higher doses (>12 grams per day).
Frequently Asked Questions
References
Sources95 references
SupplementDEX uses only high-quality sources to determine supplement effectiveness.
SupplementDEX Database · Polycystic ovary syndrome
25 references1.SupplementDEX Database: Polycystic ovary syndrome — Pharmacological and Non-Pharmacological Interventions for Polycystic Ovary Syndrome (PCOS) in Indian Women: A Systematic Review and Meta-Analysis2025
A systematic review and meta-analysis evaluated pharmacological and non-pharmacological PCOS treatments in Indian women across metabolic and reproductive outcomes.
2.SupplementDEX Database: Polycystic ovary syndrome — Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials2023
A meta-analysis of 1,691 women with PCOS found inositol effective and safe for improving metabolic, hormonal, and reproductive outcomes versus control.
3.SupplementDEX Database: Polycystic ovary syndrome — Short period-administration of myo-inositol and metformin on hormonal and glycolipid profiles in patients with polycystic ovary syndrome: a systematic review and updated meta-analysis of randomized controlled trials2022
A meta-analysis of 612 PCOS patients found short-term myo-inositol and metformin each improved hormonal and glycolipid profiles, with broadly comparable effects.
4.SupplementDEX Database: Polycystic ovary syndrome — Efficacy of myo-inositol and d-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young women with polycystic ovary syndrome: A randomized open-label study2022
In 70 young Indian women with PCOS over 6 months, myo-inositol plus D-chiro-inositol (1,400 mg/day) restored spontaneous menses in 28 patients versus hormonal contraceptive therapy.
5.SupplementDEX Database: Polycystic ovary syndrome — Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial2021
In 72 women with PCOS over 6 months, metformin plus myo-inositol and D-chiro-inositol improved metabolic and hormonal markers more than metformin alone.
6.SupplementDEX Database: Polycystic ovary syndrome — Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials2019
A meta-analysis of 355 PCOS patients found both metformin and myo-inositol improved metabolic and hormonal parameters, with broadly similar short-term effects.
7.SupplementDEX Database: Polycystic ovary syndrome — Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial2019
In 60 PCOS women undergoing ICSI over 12 weeks, myo-inositol plus higher-dose D-chiro-inositol (150 mg twice daily) affected oocyte quality differently than a lower DCI ratio.
8.SupplementDEX Database: Polycystic ovary syndrome — Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis2017
A meta-analysis (1,406 women, ages 18–44) found several nutritional supplements, including inositol, improved menstrual regulation and metabolic markers in PCOS.
9.SupplementDEX Database: Polycystic ovary syndrome — Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)2017
In 50 PCOS women, myo-inositol (4 g/day) and metformin (1,500 mg/day) each improved insulin sensitivity and reproductive markers over 6 months.
10.SupplementDEX Database: Polycystic ovary syndrome — Metformin vs myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study2017
In 34 obese PCOS women over 6 months in a crossover trial, metformin and myo-inositol produced differing metabolic and hormonal effects.
11.SupplementDEX Database: Polycystic ovary syndrome — Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance2015
In 50 anovulatory PCOS women with insulin resistance, myo-inositol alone or with clomiphene improved ovulation and pregnancy rates versus baseline.
12.SupplementDEX Database: Polycystic ovary syndrome — Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS2014
In 50 PCOS women over 6 months, myo-inositol (4 g/day) improved ovarian function and metabolism more than D-chiro-inositol alone.
13.SupplementDEX Database: Polycystic ovary syndrome — The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance2014
In 91 PCOS patients treated with inositol plus N-acetylcysteine for 12 months, menstrual regularity and ovulation improved in both insulin-resistant and non-resistant subgroups.
14.SupplementDEX Database: Polycystic ovary syndrome — The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial2013
In PCOS women undergoing IVF, combined myo-inositol plus D-chiro-inositol improved IVF outcomes more than D-chiro-inositol alone.
15.SupplementDEX Database: Polycystic ovary syndrome — The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone2012
In overweight PCOS patients, combined myo-inositol and D-chiro-inositol reduced metabolic risk factors more than myo-inositol alone.
16.SupplementDEX Database: Polycystic ovary syndrome — Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome2012
In 26 PCOS women over 12 weeks, myo-inositol (1,200 mg/day) reduced oxidative stress markers in erythrocytes versus baseline.
17.SupplementDEX Database: Polycystic ovary syndrome — Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial2011
In 84 euglycemic PCOS patients undergoing ICSI, myo-inositol (2 g twice daily) improved oocyte quality more than D-chiro-inositol.
18.SupplementDEX Database: Polycystic ovary syndrome — Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial2011
In PCOS patients over 3 months, myo-inositol (2 g/day) improved oocyte quality during fertility treatment versus control in a double-blind trial.
19.SupplementDEX Database: Polycystic ovary syndrome — Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women2010
In 120 PCOS patients, myo-inositol (4 g/day) was comparable to metformin (1,500 mg/day) for ovulation induction, alone or with r-FSH.
20.SupplementDEX Database: Polycystic ovary syndrome — Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial2009
In 42 PCOS women, myo-inositol plus folic acid over 12 weeks lowered testosterone and improved insulin sensitivity versus folic acid alone.
21.SupplementDEX Database: Polycystic ovary syndrome — Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. See external source2009
In 50 young PCOS women over 6 months, myo-inositol improved acne and hirsutism versus control.
View source200922.SupplementDEX Database: Polycystic ovary syndrome — Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome2008
In 20 overweight PCOS patients over 12 weeks, myo-inositol (2 g/day) improved hyperinsulinemia and hormonal parameters versus folic acid alone.
23.SupplementDEX Database: Polycystic ovary syndrome — Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial2003
In 45 PCOS women, inositol (200 mg/day) improved ovarian function and metabolic markers versus placebo in a double-blind trial.
24.SupplementDEX Database: Polycystic ovary syndrome — Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome2002
In 20 lean PCOS women over 6–8 weeks, D-chiro-inositol (600 mg/day) improved insulin sensitivity and ovulatory function versus placebo.
25.SupplementDEX Database: Polycystic ovary syndrome — Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome1999
In 44 PCOS women, D-chiro-inositol (1,200 mg/day) improved ovulation rates and metabolic parameters versus placebo.
SupplementDEX Database · Gestational diabetes
6 references26.SupplementDEX Database: Gestational diabetes — Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial2024
In 200 pregnant women randomized at 11–13 weeks, myo-inositol (4,000 mg/day) improved insulin resistance and reduced gestational diabetes incidence versus control.
27.SupplementDEX Database: Gestational diabetes — Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2022
A meta-analysis of RCTs (1,321 pregnant women) found inositol supplementation significantly reduced gestational diabetes risk versus control.
28.SupplementDEX Database: Gestational diabetes — Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial2020
In 223 overweight non-obese pregnant women, myo-inositol (2 g/day) reduced gestational diabetes incidence and improved body composition versus folic acid alone.
29.SupplementDEX Database: Gestational diabetes — Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes2016
In pregnant women with gestational diabetes, myo-inositol supplementation improved glycemic control during pregnancy versus control in a clinical trial.
30.SupplementDEX Database: Gestational diabetes — Myo-inositol may prevent gestational diabetes in PCOS women2012
In 98 pregnancies among women with PCOS, myo-inositol during pregnancy was associated with lower gestational diabetes rates than metformin stopped after conception.
31.SupplementDEX Database: Gestational diabetes — The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes2011
In women with gestational diabetes over 8 weeks, myo-inositol (4 g/day) improved insulin resistance markers versus control.
SupplementDEX Database · Metabolic syndrome
6 references32.SupplementDEX Database: Metabolic syndrome — Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome2024
In 58 metabolic syndrome patients on metformin, a supplement with glucomannan, D-chiro-inositol, cinnamon, and inulin improved metabolic markers versus control.
33.SupplementDEX Database: Metabolic syndrome — The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials2021
A meta-analysis of RCTs found inositol supplementation (~4,000 mg/day) did not significantly change blood pressure versus control.
34.SupplementDEX Database: Metabolic syndrome — The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials2018
A meta-analysis found inositol supplementation improved lipid profiles, especially triglycerides and HDL, in people with metabolic diseases.
35.SupplementDEX Database: Metabolic syndrome — Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial2013
In 155 postmenopausal women with metabolic syndrome at breast cancer risk, inositol plus alpha-lipoic acid improved metabolic outcomes versus placebo over 6 months.
36.SupplementDEX Database: Metabolic syndrome — One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome2012
In 80 postmenopausal women with metabolic syndrome over 12 months, myo-inositol (2 g twice daily) improved insulin sensitivity and lipid parameters versus placebo.
37.SupplementDEX Database: Metabolic syndrome — Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome2008
In hyperlipidemic subjects, 2 weeks of myo-inositol raised serum plasmalogens and reduced small dense LDL, especially in those with metabolic syndrome.
38.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD2024
In 26 obese NAFLD patients over 8 weeks, myo-inositol (4 g/day) improved insulin resistance and AMPK/PI3K/AKT signaling versus placebo.
SupplementDEX Database · Panic disorder
3 references39.SupplementDEX Database: Panic disorder — Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder2001
In 20 panic disorder patients, inositol (18 g/day) produced antipanic effects similar to fluvoxamine in a crossover trial.
40.SupplementDEX Database: Panic disorder — Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder1997
In seven panic disorder patients, a single 20 g dose of inositol did not attenuate m-CPP–induced anxiety or autonomic responses versus placebo.
41.SupplementDEX Database: Panic disorder — Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder1995
In 21 panic disorder patients over 4 weeks, inositol (12 g/day) significantly reduced panic attack frequency and severity versus placebo.
SupplementDEX Database · Preterm labor
1 reference42.SupplementDEX Database: Preterm labor — The efficacy of myo-inositol supplementation to prevent gestational diabetes onset: a meta-analysis of randomized controlled trials2019
A meta-analysis of RCTs found myo-inositol supplementation significantly reduced gestational diabetes onset in pregnant women versus control.
43.SupplementDEX Database: Acute respiratory distress syndrome — Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial2021
Follow-up of preterm infants from the NICHD inositol trial found myo-inositol supplementation did not alter neurodevelopmental outcomes at 24 months.
44.SupplementDEX Database: Acute respiratory distress syndrome — Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial2018
In 638 extremely preterm infants, myo-inositol did not reduce severe retinopathy of prematurity and was associated with higher mortality and complications versus placebo.
45.SupplementDEX Database: Acute respiratory distress syndrome — Inositol in preterm infants at risk for or having respiratory distress syndrome2015
A Cochrane meta-analysis found inositol may reduce respiratory distress in preterm infants, but evidence was inconsistent across included trials.
46.SupplementDEX Database: Acute respiratory distress syndrome — Inositol supplementation in premature infants with respiratory distress syndrome1992
In 221 preterm infants, inositol (80 mg/kg/day) for the first 5 days improved survival and reduced complications versus placebo.
47.SupplementDEX Database: Acute respiratory distress syndrome — Inositol supplementation in respiratory distress syndrome1990
In 230 preterm infants with RDS, inositol (70–100 mg/kg/day) during the first month improved lung function and reduced complications versus glucose control.
SupplementDEX Database · Anxiety
1 reference48.SupplementDEX Database: Anxiety — A meta-analysis of inositol for depression and anxiety disorders2014
A meta-analysis of 242 participants found inositol may help panic disorder but showed limited evidence for depression and other anxiety disorders.
SupplementDEX Database · Depression
9 references49.SupplementDEX Database: Depression — Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce2022
WFSBP/CANMAT 2022 guidelines rated acetyl-L-carnitine as not recommended for ADHD based on Grade A evidence from meta-analyses and RCTs.
50.SupplementDEX Database: Depression — Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone2006
In 66 patients with treatment-resistant bipolar depression over 8 weeks, inositol, lamotrigine, and risperidone augmentation each produced limited and comparable benefits.
51.SupplementDEX Database: Depression — Inositol for depressive disorders2004
A Cochrane review of inositol for depressive disorders (141 participants across trials) found mixed and generally limited evidence for antidepressant efficacy.
52.SupplementDEX Database: Depression — Combination of inositol and serotonin reuptake inhibitors in the treatment of depression1999
In 27 depressed patients over 4 weeks, adding inositol to SSRIs did not improve depression scores versus SSRI plus placebo.
53.SupplementDEX Database: Depression — Inositol addition does not improve depression in SSRI treatment failures1999
In SSRI non-responders, inositol augmentation did not improve depression versus placebo in a controlled trial.
54.SupplementDEX Database: Depression — Double-blind, controlled trial of inositol treatment of depression1995
In 28 depressed patients over 4 weeks, inositol (12 g/day) significantly improved Hamilton Depression scores versus placebo.
55.SupplementDEX Database: Depression — Follow-up and relapse analysis of an inositol study of depression1995
Follow-up of 28 depressed patients 10–12 months after inositol treatment found rapid relapse after discontinuation in responders, unlike placebo responders.
57.SupplementDEX Database: Depression — The effects of lithium discontinuation and the non-effect of oral inositol upon thyroid hormones and cortisol in patients with bipolar affective disorder1991
In euthymic bipolar patients, oral inositol did not significantly change thyroid hormones or cortisol during an 11-day trial after lithium discontinuation.
56.Inositol 6 g daily may be effective in depression but not in schizophrenia. See external sourceExternal source
SupplementDEX Database · Diabetic neuropathy
3 references58.SupplementDEX Database: Diabetic neuropathy — Oral supplementation of myoinositol: effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normals1983
In 28 young diabetics over 2 months, oral myo-inositol (6 g/day) did not improve vibratory threshold or nerve conduction versus placebo.
59.SupplementDEX Database: Diabetic neuropathy — Myoinositol and function of peripheral nerves in human diabetics. A controlled clinical trial1978
In 59 diabetic patients, myo-inositol did not change motor conduction velocity, vibratory threshold, or retinopathy versus placebo.
60.SupplementDEX Database: Diabetic neuropathy — Effect of myo-inositol on peripheral-nerve function in diabetes1978
A clinical study reported myo-inositol improved peripheral nerve function in diabetes, though published abstract details were limited.
SupplementDEX Database · Hashimoto's thyroiditis
2 references61.SupplementDEX Database: Hashimoto's thyroiditis — Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis2024
A network meta-analysis compared supplements for Hashimoto's thyroiditis and identified which interventions most effectively lowered thyroid autoantibodies and TSH.
62.SupplementDEX Database: Hashimoto's thyroiditis — Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis2024
A meta-analysis of 288 autoimmune thyroiditis patients found combined myo-inositol plus selenium improved TSH and reduced TPOAb and TgAb more than selenium alone.
63.SupplementDEX Database: Premenstrual dysphoric disorder — Myo-inositol in the treatment of premenstrual dysphoric disorder2011
In women with premenstrual dysphoric disorder, myo-inositol (0.6 g/day) improved mood and symptom severity versus control.
64.SupplementDEX Database: Premenstrual dysphoric disorder — Myo-inositol has no beneficial effect on premenstrual dysphoric disorder2002
In 11 women with PMDD, inositol (12 g/day) did not improve premenstrual symptoms versus placebo.
65.SupplementDEX Database: Retinopathy of prematurity — The efficacy and safety of inositol supplementation in preterm infants to prevent retinopathy of prematurity: a systematic review and meta-analysis2019
A meta-analysis of preterm infant trials found inositol supplementation did not clearly prevent retinopathy of prematurity.
SupplementDEX Database · Alzheimer's disease
2 references66.SupplementDEX Database: Alzheimer's disease — A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease2011
In a phase 2 RCT of 353 patients with mild-to-moderate Alzheimer disease, ELND005 (scyllo-inositol) over 78 weeks did not improve cognition or daily function versus placebo.
67.SupplementDEX Database: Alzheimer's disease — Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial1996
In 11 Alzheimer patients in a crossover trial, 6 g/day inositol for 1 month improved language and orientation modestly but showed no overall CAMCOG benefit versus placebo.
68.SupplementDEX Database: Autism spectrum disorder — Inositol treatment of autism1997
In 9 children with autism, inositol (200 mg/kg/day) showed no benefit on behavioral symptoms versus placebo in a crossover trial.
69.SupplementDEX Database: Binge eating disorder — Effect of inositol on bulimia nervosa and binge eating2001
In 12 patients with bulimia nervosa over 6 weeks, inositol (18 g/day) reduced binge frequency and eating disorder scores versus placebo.
SupplementDEX Database · Bipolar disorder
3 references70.SupplementDEX Database: Bipolar disorder — A Randomized, Double-Blind, Controlled Clinical Trial of Omega-3 Fatty Acids and Inositol as Monotherapies and in Combination for the Treatment of Pediatric Bipolar Spectrum Disorder in Children Age 5-122022
In children aged 5–12 with bipolar spectrum disorder, omega-3 fatty acids, inositol, and their combination produced modest symptom improvements versus control.
71.SupplementDEX Database: Bipolar disorder — A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study2015
In a pilot RCT of 10 children (ages 5–12) with bipolar spectrum disorder, high-EPA omega-3 and inositol showed preliminary but limited efficacy over 12 weeks.
72.SupplementDEX Database: Bipolar disorder — Inositol as an add-on treatment for bipolar depression. See external source2000
In 24 adults with bipolar depression over 6 weeks, inositol add-on (12 g/day) improved depressive symptoms versus placebo when added to standard treatment.
View source2000
73.SupplementDEX Database: Erectile dysfunction — Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study2023
In 15 overweight men with subclinical hypogonadism, a nutraceutical containing myoinositol, alpha-lipoic acid, and folic acid added to lifestyle changes for 3 months improved BMI, insulin sensitivity, and testosterone versus baseline.
SupplementDEX Database · Infertility
7 references74.SupplementDEX Database: Infertility — Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial2023
A secondary analysis of the NiPPeR trial (736 women, ages 18–38) found a myo-inositol, probiotic, and micronutrient supplement modestly improved time to conception versus standard supplement.
75.SupplementDEX Database: Infertility — Myo-inositol effect on pregnancy outcomes in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: A double-blind RCT2022
In 70 infertile women undergoing IVF/ICSI, myo-inositol for 2 months improved pregnancy outcomes versus control in a double-blind RCT.
76.SupplementDEX Database: Infertility — Effects of Oral Supplementation with Myo-Inositol and D-Chiro-Inositol on Ovarian Functions in Female Long-Term Survivors of Lymphoma: Results from a Prospective Case-Control Analysis2022
In female long-term lymphoma survivors, myo-inositol plus D-chiro-inositol (135 mg/day) over 12 months improved ovarian function markers versus untreated controls.
77.SupplementDEX Database: Infertility — Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis2022
A meta-analysis (4,668 women with PCOS) found inositol alone or with metformin improved assisted reproduction outcomes versus control.
78.SupplementDEX Database: Infertility — The effect of Myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial2021
In 60 poor ovarian responders undergoing ART, myo-inositol improved fertility rates and ovarian response versus control.
79.SupplementDEX Database: Infertility — Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: A randomized controlled trial2020
In 112 poor ovarian responders, myo-inositol (4 g/day) for 1 month before ICSI improved oocyte quality and reproductive outcomes versus folic acid alone.
80.SupplementDEX Database: Infertility — Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study2012
In 100 non-PCOS IVF patients, 3 months of myo-inositol pretreatment improved ovarian response and reduced gonadotropin requirements versus control.
SupplementDEX Database · Hirsutism
1 reference81.SupplementDEX Database: Hirsutism — Treatment of hirsutism with myo-inositol: a prospective clinical study2008
In 46 women with hirsutism over 6 months, myo-inositol reduced hirsutism scores and improved related hormonal and lipid parameters.
SupplementDEX Database · Hypothyroidism
2 references82.SupplementDEX Database: Hypothyroidism — Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis2024
A meta-analysis found combined selenium and myo-inositol improved thyroid function and reduced autoantibodies in thyroid disease versus control.
83.SupplementDEX Database: Hypothyroidism — Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism2022
In 148 women with subclinical hypothyroidism over 6 months, myo-inositol plus selenium (600 mg plus 83 mcg/day) improved TSH, autoantibodies, and symptoms.
SupplementDEX Database · Insomnia
1 reference84.SupplementDEX Database: Insomnia — The impact of myo-inositol supplementation on sleep quality in pregnant women: a randomized, double-blind, placebo-controlled study2020
In 60 pregnant women over 10 weeks, myo-inositol (2,000 mg/day) improved sleep quality and reduced sleep disturbances versus placebo.
SupplementDEX Database · Lung cancer
2 references85.SupplementDEX Database: Lung cancer — A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia2016
In 38 smokers with bronchial dysplasia over 6 months, myo-inositol (9 g/day) led to regression of dysplastic lesions versus placebo in a phase IIb trial.
86.SupplementDEX Database: Lung cancer — A phase I study of myo-inositol for lung cancer chemoprevention2006
In a phase I dose-escalation study of 16 high-risk smokers, myo-inositol (12–30 g/day for 1 month) was tolerable and associated with reduced dysplasia markers.
SupplementDEX Database · Mastalgia
1 reference87.SupplementDEX Database: Mastalgia — Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study2024
A retrospective study of 15 fertile women (ages 20–45) found a topical breast gel with Boswellia, betaine, and myo-inositol improved cyclic mastodynia.
SupplementDEX Database · Obesity
1 reference88.SupplementDEX Database: Obesity — Inositol supplementation and body mass index: A systematic review and meta-analysis of randomized clinical trials2021
A meta-analysis of RCTs found inositol supplementation produced modest but significant reductions in body mass index versus control.
89.SupplementDEX Database: Obsessive-compulsive disorder (OCD) — Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: a double-blind cross-over study1999
In 10 OCD patients on SSRIs over 6 weeks, inositol augmentation (18 g/day) did not significantly improve OCD symptoms versus placebo.
90.SupplementDEX Database: Obsessive-compulsive disorder (OCD) — Inositol treatment of obsessive-compulsive disorder1996
In 13 OCD patients over 6 weeks, inositol monotherapy (18 g/day) significantly reduced Yale-Brown Obsessive-Compulsive Scale scores versus placebo.
91.SupplementDEX Database: Post-traumatic stress disorder — Inositol treatment of post-traumatic stress disorder1996
In a controlled trial, inositol did not significantly improve PTSD symptoms versus placebo.
SupplementDEX Database · Psoriasis
1 reference92.SupplementDEX Database: Psoriasis — The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial2004
In 15 psoriasis patients on lithium, inositol supplementation improved psoriasis severity versus placebo in a randomized trial.
SupplementDEX Database · Schizophrenia
3 references93.SupplementDEX Database: Schizophrenia — CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia1994
In 12 anergic schizophrenia patients, high-dose inositol (12 g/day for 1 month) did not improve symptoms; CSF inositol levels did not differ from controls.
95.SupplementDEX Database: Schizophrenia — Lack of effect of inositol treatment in chronic schizophrenia1993
In patients with chronic schizophrenia, inositol treatment produced no symptom improvement versus control.
94.Inositol 6 g daily may be effective in depression but not in schizophrenia. See external sourceExternal source