Longevity

Overview

Vitamin D has medium-strength evidence for longevity. Vitamin D3 supplementation may slightly lower death risk in older adults over five years, particularly from cancer, though other vitamin D forms do not show the same benefit. Vitamin D3 with calcium may increase kidney stone risk.

N-Acetyl Cysteine (NAC) has insufficient evidence from two studies. An Astragalus-based supplement increased telomere length and telomerase activity over six months in healthy middle-aged adults with no reported side effects, though long-term health effects are not established. The heatmap and evidence reviews below compare these supplements.

Effect graph

Relevant supplements

Relevant supplements sorted by DEX Score.

Studies

Find individual evidence reviews for supplements sorted by DEX Score.

Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.