Liver transplantation

Overview

SupplementDEX currently indexes N-Acetyl Cysteine for liver transplantation. See the heatmap and evidence reviews below for the full rating.

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N-Acetyl Cysteine (NAC)	★★★★★	Low

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Studies

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1 supplement for rated at least stars. All purchase bands. No minimum star filter.

N-Acetyl Cysteine (NAC)View supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceMediumTrustMedium

Hospital IV/IM therapy — not an oral supplement

Evidence Review

Receiving intravenous N-acetyl cysteine during liver transplant surgery does not seem to improve outcomes.
It has not been studied whether taking NAC by mouth helps in liver transplants.

Browse 2 studies1 meta-analysis

MetaN-acetylcysteine in the Donor, Recipient, or Both Donor and Recipient in Liver Transplantation: A Systematic Review With Meta-analysis and Trial Sequential Analysis2023n=1,121

A meta-analysis of 1,121 liver transplant patients found NAC reduced primary graft nonfunction, postoperative complications, and peak transaminase levels.

Effect: Benefit
Participants: 1,121

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RCTA prospective randomized trial of N-acetyl cysteine administration during cold preservation of the donor liver for transplantation2005n=9

A randomized trial of 18 liver transplant recipients found donor NAC administration during cold preservation did not significantly reduce reperfusion injury versus control.

Effect: No Benefit
Population: Liver transplant patients
Participants: 9

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

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Effect-size distribution

How large the reported benefits tend to be

Study distribution across 1 supplements for liver transplantation (2 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
N-Acetyl Cysteine (NAC)	★★★★★48%	2	1	100%

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Overview

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Studies

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