Liver health

Overview

SAMe did not provide additional liver benefit beyond stopping alcohol in alcoholic liver disease in one 24-week study. A separate study in patients who developed liver problems during chemotherapy also found no extra benefit from AdoMet compared with placebo.

L-Carnitine and Resveratrol have insufficient evidence for liver health based on very limited data. See the evidence reviews below for available research.

Effect graph

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Relevant supplements

Relevant supplements sorted by DEX Score.


Resveratrol	★★★★★	Low
SAMe	★★★★★	Low
L-Carnitine	★★★★★	Low

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Studies

Find individual evidence reviews for supplements sorted by DEX Score.

3 supplements for rated at least stars. All purchase bands. No minimum star filter.

ResveratrolView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceMediumTrustMedium

Evidence Review

Resveratrol has insufficient evidence for Liver health.

Browse 1 study1 meta-analysis

MetaEffects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials2021n=714

A meta-analysis found resveratrol supplementation significantly reduced ALT and AST in adults, suggesting modest liver enzyme improvements.

Effect: Benefit
Population: Adults
Participants: 714

View on PubMed

L-CarnitineView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

There is not enough evidence to determine if L-carnitine has any benefit for liver health.

Browse 1 study

RCTEffects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial study2025

In pediatric acute lymphoblastic leukemia, oral L-carnitine 50 mg/kg for 2 months reduced chemotherapy-related liver enzyme elevations versus control.

Effect: Benefit
Duration: 2 months
Dose: 50 mg/kg
Population: Children/adolescents
Ages: >5

View on PubMed

SAMeView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

A study tested if taking SAM supplements every day for 24 weeks could help people with alcoholic liver disease.
All participants stopped drinking alcohol, which helped improve their liver health.
However, those who took SAM did not do better than those who took a placebo.
This means SAM did not provide extra benefit beyond what stopping drinking already offered.
This study looked at whether a supplement called AdoMet (SAMe) can protect the liver during cancer chemotherapy.
In 50 patients who developed liver problems from chemotherapy, taking AdoMet by mouth helped lower liver enzyme levels within a week.
This improvement lasted during later chemotherapy treatments and helped patients stick to their planned treatment schedules with fewer delays or dose changes.
No side effects were seen.
More research is needed to confirm these findings.

Browse 2 studies

RCTS-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial2011n=37

A 24-week RCT in 37 alcoholic liver disease patients found SAM 1.2 g/day was no more effective than placebo for liver enzymes or histology, though abstinence improved liver function in both groups.

Effect: No Benefit
Duration: 24 weeks
Dose: 1.2 g/day
Population: Patients with alcoholic liver disease
Participants: 37

View on PubMed

Clinical trialS-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury2003

In 50 cancer patients with first-time chemotherapy-induced liver toxicity, oral AdoMet significantly reduced AST, ALT, and LDH within 1–2 weeks and allowed scheduled chemotherapy with fewer dose delays.

Effect: Benefit
Population: Cancer patients

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 3 supplements for liver health (4 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
SAMe	★★★★★44%	2	0	50%
L-Carnitine	★★★★★44%	1	0	25%
Resveratrol	★★★★★48%	1	1	25%

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Overview

Effect graph

Relevant supplements

Studies

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