Lactose intolerance
Supplements studied for Lactose intolerance.
Overview
SupplementDEX currently indexes Lactase for lactose intolerance. See the heatmap and evidence reviews below for the full rating.
Effect graph
Relevant supplements
Relevant supplements sorted by DEX Score.
| Lactase | ★★★★★ | High |
Studies
Find individual evidence reviews for supplements sorted by DEX Score.
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LactaseView supplement →
Consider purchase·★★★★★
How we scored this▸
- Lactase supplements are effective for reducing symptoms like cramps, gas, and stomach discomfort in people with lactose intolerance.
Browse 11 studies
RCTEffect of lactase on symptoms and hydrogen breath levels in lactose intolerance: A crossover placebo-controlled study2020n=47
In 47 lactose-intolerant adults, lactase chewable tablets reduced symptoms and hydrogen breath levels during lactose challenge versus placebo.
- Effect
- Benefit
- Dose
- 25 g/day
- Population
- Adults
- Participants
- 47
- Avg age
- ~34
RCTA combination of acid lactase from Aspergillus oryzae and yogurt bacteria improves lactose digestion in lactose maldigesters synergistically: A randomized, controlled, double-blind cross-over trial2014
In 24 lactose malabsorbers, acid lactase from Aspergillus oryzae plus yogurt bacteria improved lactose digestion more than either alone versus placebo.
- Effect
- Benefit
- Dose
- 12.5 g
RCTThe effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial2010n=20
In 60 lactose-intolerant patients, tilactase or Lactobacillus reuteri before lactose breath test reduced hydrogen excretion and symptoms versus placebo.
- Effect
- Benefit
- Duration
- 10 days
- Population
- Lactose intolerant patients
- Participants
- 20
Clinical trialEffect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study2005
In 30 lactose malabsorbers, beta-galactosidase from Kluyveromyces lactis added to milk reduced hydrogen breath excretion and symptoms versus placebo.
- Effect
- Benefit
- Dose
- 3000–6000 UI per 400 ml milk
- Population
- Older adults
- Ages
- 18–65
RCTAll lactase preparations are not the same: results of a prospective, randomized, placebo-controlled trial1994
In 10 lactose-intolerant adults, three commercial lactase products differed in efficacy for reducing symptoms and breath hydrogen after 18 g lactose challenge.
- Effect
- Benefit
- Dose
- 18 g/day
- Population
- Healthy adults
RCTComparative effects of exogenous lactase (beta-galactosidase) preparations on in vivo lactose digestion1993
In lactose maldigesters, Lactogest, Lactaid, and DairyEase beta-galactosidase preparations dramatically reduced breath hydrogen with 20 g or 50 g lactose versus placebo.
- Effect
- Benefit
- Dose
- 3000–6000 IU per dose
Controlled trialbeta-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study1992
In 16 lactose-malabsorbing adults, Aspergillus niger beta-galactosidase added to 400 ml milk significantly reduced breath hydrogen versus placebo.
- Effect
- Benefit
- Population
- Adults
RCTEffect of a single dose of lactase on symptoms and expired hydrogen after lactose challenge in lactose-intolerant subjects1992n=21
In 21 lactose-intolerant subjects, a single dose of 9,900 FCC-unit lactase before 37.5 g lactose in milk reduced symptoms and breath hydrogen versus placebo.
- Effect
- Benefit
- Dose
- 37.5 g/day
- Participants
- 21
RCTDietary manipulation of postprandial colonic lactose fermentation: II. Addition of exogenous, microbial beta-galactosidases at mealtime1985
In lactose-malabsorbing adults, microbial beta-galactosidase enzymes added to milk at mealtime reduced postprandial hydrogen excretion versus untreated milk.
- Effect
- Benefit
- Population
- Adults
RCTEnzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime1984n=25
In 25 adult lactose malabsorbers, yeast or fungal lactase enzymes in 360 ml milk reduced breath hydrogen up to 53% versus untreated milk.
- Effect
- Benefit
- Dose
- 1–1.5 g
- Population
- Adults
- Participants
- 25
Controlled trialLong-term acceptance of low-lactose milk1979
In 31 lactose-intolerant and 16 tolerant adults, 500 ml low-lactose milk twice daily for 1 month was well tolerated with fewer symptoms than regular milk.
- Effect
- Benefit
- Duration
- 1 month
- Dose
- 500 mL 2×/day
- Population
- Adults
Evidence visualised
Same ratings as above, aggregated so you can see coverage and imbalance.
| Supplement | DEX | Studies | Meta-analyses | Share |
|---|---|---|---|---|
| Lactase | ★★★★★76% | 11 | 0 | 100% |