Xylitol

In an RCT in adults, for 1 month, the rapid reduction in IL-1β and TNF-α after 1 month of use of the intervention composition suggests a safe and effective novel strategy for reducing pro-inflammatory cytokines that may offer an opportunity to diminish the inflammatory status in patients with overweight/pre-obesity.

In an RCT of 12 participants, samples in 2 groups had no significant difference in age and sex.

In an RCT of 59 participants, for 6 months, regular use of xylitol did not prevent AOM, URTIs or dental caries in a trial with limited statistical power.

In an RCT in children, for 10 years, key words: Xylitol, dental caries, dental demineralization, Streptococcus mutans, prevention.

In a meta-analysis of 6,325 participants, the use of xylitol or sorbitol as sugar substitutes has a beneficial effect in preventing dental caries among children and adolescents.

In an RCT of 30 participants, for 30 days, mutans .

In a meta-analysis in children/adolescents, caries incidences at the child level were compared using odds ratios (ORs) with 95% CI.

In a systematic review in adults, when looking more specifically at xylitol gum, the results of the meta-analysis showed that it significantly reduced plaque quantity (effect size-0.743; 95% CI-1.148 to-0.338).

In a study of 20 participants, our preliminary data confirm and improve the main results reported in the scientific literature on the importance of the use of xylitol, lysozyme, and sea salt in oral health.

In a meta-analysis in children/adolescents, the present systematic review examining the effectiveness of xylitol on caries incidence in children showed a small effect size in randomized controlled trials and a very low quality of evidence that makes preventive action of xylitol uncertain.

In a meta-analysis in children/adolescents, xylitol was found to be an effective strategy as self-applied caries preventive agent.

In a meta-analysis of 5,903 participants, 8 g/day, for 1 year, one study reported that xylitol syrup (8 g per day) reduced caries by 58% (95% CI 33% to 83%, 94 infants analysed, low quality evidence) when compared to a low-dose xylitol syrup (2.67 g per day) consumed for 1 year.The following results had 95% CIs that were compatible...

In a study in children/adolescents, (I Statement).

In a systematic review, articles were excluded if they did not report computable data or did not follow up test and control groups in the same way.

In a systematic review in children/adolescents, the studies must have had the following characteristics: (a) a comparison of caries progression in subjects who either did or did not consume candies or lozenges containing xylitol during a minimum follow-up period of 1 year; and (b) a concurrent comparison of the percentage of caries...

In a study of 17 participants, one percent chlorhexidine varnish associated with 40% xylitol solution tested in the present study does not provide significant suppression of Streptococcus mutans counts and reduction of plaque accumulation at any follow-up time points.

In a systematic review, for 20–40 months, the data suggest that xylitol-containing gums may provide superior efficacy in reducing caries rates in high-risk populations.

In a study, the validity of the theory can be verified in controlled clinical trials.

In an observational study of 68 participants, for 3 months, the findings support the effectiveness and safety of nasal xylitol spray, for preventing recurrent AOM in children aged 1-4 years.

In a meta-analysis of 3,405 participants, xylitol was not effective in reducing AOM among healthy children during a respiratory infection (RR 1.13, 95% CI 0.83 to 1.53; moderate quality evidence) or among otitis-prone healthy children (RR 0.90, 95% CI 0.67 to 1.21; low-quality evidence).

In a meta-analysis of 1,826 participants, among the reasons for drop-outs, there were no significant differences in abdominal discomfort and rash between the xylitol and the control groups.

In an RCT of 1,277 participants, xylitol administered only during an ARI was ineffective in preventing AOM.

In an RCT of 179 participants, 8.4–10 g xylitol/day, xylitol sugar, when given in a syrup or chewing gum, was effective in preventing AOM and decreasing the need for antimicrobials.

In an RCT of 306 participants, 8.4 g/day, xylitol seems to have a preventive effect against acute otitis media.

In an RCT of 14 participants, 24 g xylitol/day, for 5 weeks, nCT02821923.

In an RCT of 40 participants, for 26 weeks, 1b, individual randomized controlled trial.

In a study of 30 participants, for 30 days, xNI results in greater improvement of symptoms of CRS and greater enhancement of nasal NO and iNOS mRNA in maxillary sinus as compared to SNI.

In an RCT of 20 participants, in the short term, xylitol irrigations result in greater improvement of symptoms of chronic rhinosinusitis as compared to saline irrigation.