Nonmelanoma skin cancer

Overview

SupplementDEX lists 3 supplements studied for nonmelanoma skin cancer across 4 trials. The strongest indexed signals include Caffeine, Vitamin A, Vitamin D. See the heatmap and evidence reviews below for full ratings across all supplements.

Effect graph

Unlock now

Relevant supplements

Relevant supplements sorted by DEX Score.


Caffeine	★★★★★	Low
Vitamin A	★★★★★	Low
Vitamin D	★★★★★	Very Low / None

Unlock now

Studies

Find individual evidence reviews for supplements sorted by DEX Score.

3 supplements for and rated at least stars. All purchase bands. No minimum star filter.

CaffeineView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceMediumTrustMedium

Evidence Review

Caffeine may help protect against nonmelanoma skin cancer, with evidence suggesting that drinking more coffee lowers the risk.
Several large studies found a clear trend: the more coffee people drink, the lower their chance of developing this common type of skin cancer.
For example, drinking one cup daily showed a small protective effect, while having more than three cups a day offered even greater benefits.
In fact, some research found that drinking six or more cups of caffeinated coffee daily was linked to a 36% lower risk of nonmelanoma skin cancer.

Browse 2 studies1 meta-analysis

MetaCoffee consumption and risk of nonmelanoma skin cancer: a dose-response meta-analysis2016

A dose-response meta-analysis found higher coffee intake associated with lower nonmelanoma skin cancer risk, with summary RRs of 0.96 (1 cup/day) down to 0.81 (>3 cups/day), especially for basal cell carcinoma.

Effect: Benefit

View on PubMed

ObservationalDaily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian women2007n=93

In 93,676 Women's Health Initiative participants, daily caffeinated coffee consumption showed a dose-related association with lower self-reported nonmelanoma skin cancer prevalence in Caucasian women, up to ~30% reduction at ≥6 cups/day.

Effect: Benefit
Population: Women
Participants: 93

View on PubMed

Vitamin AView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustLow

Evidence Review

Eating more vitamin A through diet may help lower the chance of developing a common skin cancer called squamous cell carcinoma by about 12%.
But there is no strong evidence that taking vitamin A supplements can prevent this type of skin cancer.

Browse 1 study

ObservationalAssociation of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States2019n=400

A study of 400 found that increased intake of dietary vitamin A is associated with decreased risk of incident SCC.

Effect: Benefit
Population: Adults
Participants: 400
Avg age: ~50

View on PubMed

Vitamin DView supplement →

Do not purchase★★★★★

How we scored this

Effect SizeVery Low / NoneEvidenceLowTrustMedium

Evidence Review

It is unclear if taking vitamin D alone helps prevent common skin cancers like basal cell or squamous cell carcinoma.
In adults with previous colon polyps, taking vitamin D daily (1000 IU) for several years did not lower the chances of getting these skin cancers.
Taking vitamin D combined with calcium may lower the risk of one type of skin cancer (squamous cell), but does not affect the risk of basal cell cancer.
Vitamin D by itself does not seem to protect against these skin cancers.

Browse 1 study

RCTRisk of keratinocyte carcinomas with vitamin D and calcium supplementation: a secondary analysis of a randomized clinical trial2020n=2,259

In a 8-year follow-up of 2,259 adults, vitamin D 1,000 IU/day did not reduce basal cell carcinoma risk; calcium plus vitamin D may reduce squamous cell carcinoma risk (HR 0.42).

Effect: No Benefit
Dose: 1000 IU/day
Population: Adults
Participants: 2,259
Ages: 45–75

View on PubMed

Unlock now

Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

Purchase-guidance distribution

How many supplements fall in each purchase band

Effect-size distribution

How large the reported benefits tend to be

Study distribution across 3 supplements for nonmelanoma skin cancer (4 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Caffeine	★★★★★48%	2	1	50%
Vitamin A	★★★★★40%	1	0	25%
Vitamin D	★★★★★32%	1	0	25%

Unlock now

Overview

Effect graph

Relevant supplements

Studies

Evidence visualised

On this page