Resveratrol
Resveratrol is a polyphenol studied for metabolic and cardiovascular biomarkers. Clinical outcome evidence is still mixed.
Overview
What is resveratrol?
Resveratrol is a compound found in many plant sources including blueberries, red wine and grapes. It has anti-inflammatory and antioxidant properties that benefit cardiovascular function, glycemic control, and lipid metabolism. There is limited evidence from high quality human studies that resveratrol is beneficial for longevity.
Dosage
A typical dose of resveratrol is 100–3,000 mg per day. Higher doses of up to 5,000 mg per day have been used but may cause gastrointestinal upset.
Effect graph
Effect heatmap
SupplementDEX Database
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Database Snapshot
Most resveratrol research is concentrated in a handful of conditions.
- Type 2 diabetes accounts for 24 of 112 studies (21%).
- Metabolic syndrome accounts for 14 of 112 studies (13%).
- Cardiovascular disease accounts for 9 of 112 studies (8%).
- Sparse coverage remains for Chronic kidney disease, Cognitive performance, Dyslipidemia.
Dietary Sources
Top dietary sources
Food sources
Sources include Blueberries, Cranberries, Dark Chocolate, Grapes, Peanuts, Pistachios, and Walnuts.
Safety
Oral resveratrol is possibly safe at doses of up to 1,000 mg per day. Oral resveratrol may interact with drugs that utilise cytochrome P450 isoenzymes.
Frequently Asked Questions
References
Sources78 references
SupplementDEX uses only high-quality sources to determine supplement effectiveness.
SupplementDEX Database · Chronic kidney disease
2 references1.SupplementDEX Database: Chronic kidney disease — Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials2023
A meta-analysis found resveratrol supplementation produced small improvements in estimated glomerular filtration rate versus placebo in general adult populations.
2.SupplementDEX Database: Chronic kidney disease — Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials2020
A meta-analysis found resveratrol supplementation significantly reduced liver enzymes and improved some NAFLD markers versus placebo in clinical trials.
SupplementDEX Database · Dyslipidemia
2 references3.SupplementDEX Database: Dyslipidemia — Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis2024
A systematic review found resveratrol supplementation modestly improved lipid profiles in postmenopausal women, though trial quality and doses varied.
4.SupplementDEX Database: Dyslipidemia — Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review2022
A meta-analysis found resveratrol supplementation improved glucose and lipid metabolism markers, with effects varying by dose and population.
SupplementDEX Database · Hay fever
2 references5.SupplementDEX Database: Hay fever — Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis2018
In 151 adults with allergic rhinitis, resveratrol reduced nasal symptoms similarly to budesonide and better than placebo over the treatment period.
6.SupplementDEX Database: Hay fever — Resveratrol plus carboxymethyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis2014
In 68 children with pollen allergic rhinitis, resveratrol plus carboxymethyl-β-glucan reduced nasal symptoms versus placebo.
7.SupplementDEX Database: Irritable bowel syndrome — Efficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: A systematic literature review and meta-analysis2021
A meta-analysis found biophenol-rich nutraceuticals including resveratrol modestly improved GI symptoms in IBD and IBS versus usual care, with heterogeneous evidence.
8.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — Effects of resveratrol supplementation on serum concentrations of plasminogen activator inhibitor-1, fibroblast growth factor 21, and adiponectin in patients with nonalcoholic fatty liver disease2025
In NAFLD patients, resveratrol supplementation lowered PAI-1, hs-CRP, and adiponectin versus placebo over the intervention period.
9.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials2021
An overview of meta-analyses found resveratrol produced small improvements in some cardiometabolic markers in T2DM, MetS, and NAFLD, with low certainty for many outcomes.
10.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials2018
A meta-analysis found resveratrol reduced inflammatory and oxidative stress biomarkers in metabolic syndrome patients, though heterogeneity was high.
11.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — No effect of resveratrol on VLDL-TG kinetics and insulin sensitivity in obese men with nonalcoholic fatty liver disease2018
In obese men with NAFLD, resveratrol 500 mg three times daily for 6 months did not improve VLDL-triglyceride kinetics or insulin sensitivity versus placebo.
12.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — Resveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-analysis2017
A meta-analysis of NAFLD RCTs (158 participants pooled) found resveratrol significantly reduced ALT and AST versus placebo, with inconsistent effects on liver fat.
13.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — Efficacy of Resveratrol Supplementation against Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Placebo-Controlled Clinical Trials2016
A meta-analysis found resveratrol improved some NAFLD parameters such as liver enzymes and steatosis, though clinical outcomes remained inconsistent.
14.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — Resveratrol does not benefit patients with nonalcoholic fatty liver disease2014
In overweight men with NAFLD, resveratrol 300 mg/day for 30 days did not reduce hepatic steatosis or insulin resistance versus placebo.
15.SupplementDEX Database: Nonalcoholic fatty liver disease (NAFLD) — Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease2014
In 50 NAFLD patients, resveratrol 500 mg/day for 12 weeks reduced inflammatory biomarkers and improved liver fat versus placebo with lifestyle advice.
SupplementDEX Database · Obesity
3 references16.SupplementDEX Database: Obesity — Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials2025
A systematic review found polyphenol supplementation produced modest reductions in adiposity measures, with resveratrol among the better-studied agents.
17.SupplementDEX Database: Obesity — Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials2019
A meta-analysis of 28 trials found resveratrol significantly reduced body weight and BMI in adults, with larger effects at higher doses.
18.SupplementDEX Database: Obesity — Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials2014
A meta-analysis of 11 RCTs (388 participants) found resveratrol did not significantly improve fasting glucose or insulin sensitivity overall versus placebo.
19.SupplementDEX Database: Polycystic ovary syndrome (PCOS) — Effects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials2024
A meta-analysis of 3 PCOS trials found resveratrol lowered testosterone and improved some metabolic labs, though evidence remained limited.
20.SupplementDEX Database: Polycystic ovary syndrome (PCOS) — Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials2023
A systematic review found resveratrol may reduce testosterone and improve metabolic parameters in PCOS women, but trial data were sparse and inconsistent.
21.SupplementDEX Database: Polycystic ovary syndrome (PCOS) — Effect of resveratrol on menstrual cyclicity, hyperandrogenism and metabolic profile in women with PCOS2021
A double-blind RCT in 57 adults with mild-to-moderate depression found SHR-5 Rhodiola rosea extract significantly reduced HAMD and Beck Depression scores versus placebo over 6 weeks.
22.SupplementDEX Database: Polycystic ovary syndrome (PCOS) — Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial2016
In 57 adults with mild-to-moderate depression, SHR-5 Rhodiola rosea extract reduced depression rating scores versus placebo over 6 weeks in a phase III trial.
SupplementDEX Database · Type 2 diabetes
18 references23.SupplementDEX Database: Type 2 diabetes — The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis2025
In 48 nursing students on shift work, Rhodiola rosea did not significantly reduce mental or physical fatigue versus placebo over the study period.
24.SupplementDEX Database: Type 2 diabetes — Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials2022
A meta-analysis of RCTs found resveratrol supplementation significantly improved flow-mediated dilation and lowered ICAM-1 versus placebo in adults with cardiometabolic risk.
25.SupplementDEX Database: Type 2 diabetes — Effects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2022
In 30 adults, Rhodiola rosea or ADAPT-232 reduced ultra-weak photon emission versus placebo, suggesting adaptogen-related biophysical effects in this pilot.
26.SupplementDEX Database: Type 2 diabetes — Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis2022
In 60 adults with stress-related fatigue, SHR-5 Rhodiola rosea 4 tablets daily improved fatigue, cognition, and stress symptoms versus placebo.
27.SupplementDEX Database: Type 2 diabetes — The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis2022
In foreign students, the adaptogen preparation rodakson based on Rhodiola rosea improved work capacity, coordination, and reduced fatigue versus baseline.
28.SupplementDEX Database: Type 2 diabetes — Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health2021
A meta-analysis found red wine polyphenols and resveratrol improved some vascular function measures in human trials, though effects were modest.
29.SupplementDEX Database: Type 2 diabetes — Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysis2021
In 10 adults with generalized anxiety disorder, Rhodiola rosea (Rhodax) reduced Hamilton Anxiety scores versus baseline in this open-label pilot study.
30.SupplementDEX Database: Type 2 diabetes — The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials2020
A meta-analysis in metabolic syndrome patients found resveratrol improved some lipid profiles and liver enzymes, though results varied by outcome.
31.SupplementDEX Database: Type 2 diabetes — Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2019
In 220 menopausal women, a black cohosh plus Rhodiola combination reduced Kupperman menopausal scores more than black cohosh alone or placebo over 12 weeks.
32.SupplementDEX Database: Type 2 diabetes — Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials2019
A meta-analysis of RCTs (658 participants) found resveratrol significantly lowered CRP and TNF-α but not IL-6 versus placebo.
33.SupplementDEX Database: Type 2 diabetes — Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial2019
In 60 type 2 diabetic patients with albuminuria, resveratrol 500 mg/day for 90 days reduced urinary albumin/creatinine ratio versus placebo alongside losartan.
34.SupplementDEX Database: Type 2 diabetes — The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2019
A meta-analysis in metabolic syndrome found resveratrol improved endothelial function in some trials but did not consistently lower blood pressure versus placebo.
35.SupplementDEX Database: Type 2 diabetes — Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis2018
An umbrella meta-analysis in middle-age and older adults found resveratrol modestly lowered IL-6 and CRP among anti-inflammatory interventions for chronic low-grade inflammation.
36.SupplementDEX Database: Type 2 diabetes — Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial2016
In endurance athletes, Rhodiola rosea supplementation did not reduce in vivo inflammatory activity after continuous exercise versus control.
37.SupplementDEX Database: Type 2 diabetes — Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial2016
In 15 volunteers at simulated 4600 m altitude, 7-day Rhodiola rosea did not improve capillary oxygenation versus placebo or oxygenated water.
38.SupplementDEX Database: Type 2 diabetes — Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis2015
In endurance athletes, Rhodiola rosea did not reduce in vivo inflammatory activity after continuous exercise compared with control conditions.
39.SupplementDEX Database: Type 2 diabetes — Pilot study of resveratrol in older adults with impaired glucose tolerance2012
In marathon runners, Rhodiola rosea before a race did not significantly reduce muscle damage, DOMS, or cytokines versus placebo.
40.SupplementDEX Database: Type 2 diabetes — Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients2011
In healthy volunteers after exhaustive exercise, Rhodiola rosea reduced C-reactive protein and creatine kinase elevations versus control.
SupplementDEX Database · Ulcerative colitis
1 reference41.SupplementDEX Database: Ulcerative colitis — Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study2015
In men with lifelong premature ejaculation, EndEP (Rhodiola, folic acid, zinc, biotin) improved ejaculatory control and satisfaction versus baseline.
SupplementDEX Database · Acne
1 reference42.SupplementDEX Database: Acne — Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study2011
In 20 adults with acne over 60 days, a resveratrol-containing gel reduced inflammatory lesions versus vehicle control in this single-blind pilot study.
43.SupplementDEX Database: Athletic performance — Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans2014
In 16 recreationally active men over 4 weeks of HIIT, daily resveratrol 150 mg did not augment training-induced fitness or muscle fiber adaptations versus placebo.
SupplementDEX Database · Cardiovascular disease
3 references44.SupplementDEX Database: Cardiovascular disease — Resveratrol levels and all-cause mortality in older community-dwelling adults2014
In 783 older community-dwelling adults, higher urinary resveratrol metabolites were not associated with lower mortality, inflammation, or cardiovascular disease.
45.SupplementDEX Database: Cardiovascular disease — Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men2013
In aged men, 250 mg/day resveratrol during exercise training blunted expected gains in cardiovascular health and HDL cholesterol versus exercise plus placebo.
46.SupplementDEX Database: Cardiovascular disease — Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease2012
In post-MI patients over 3 months, resveratrol 10 mg/day improved flow-mediated vasodilation and select hemorheological parameters versus placebo.
SupplementDEX Database · Cognitive performance
2 references47.SupplementDEX Database: Cognitive performance — The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans2015
In 60 healthy adults, 28 days of trans-resveratrol did not significantly improve cognitive performance or cerebral blood flow versus placebo.
48.SupplementDEX Database: Cognitive performance — Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation2010
In 22 healthy adults, single doses of resveratrol 250–500 mg modulated localized cerebral blood flow but did not clearly improve cognitive performance.
SupplementDEX Database · High cholesterol
3 references49.SupplementDEX Database: High cholesterol — Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol2023
In 48 healthy adults aged 55–65, 30 days of resveratrol or caloric restriction did not significantly improve vascular reactivity despite changes in SIRT1 markers.
50.SupplementDEX Database: High cholesterol — The Effect of Resveratrol on Blood Lipid Profile: A Dose-Response Meta-Analysis of Randomized Controlled Trials2022
A dose-response meta-analysis found resveratrol supplementation significantly lowered total cholesterol by about 10 mg/dL, with stronger effects at higher doses.
51.SupplementDEX Database: High cholesterol — Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials2013
A meta-analysis of 7 trials (282 subjects) found resveratrol had no significant effect on total cholesterol, LDL, or HDL versus placebo overall.
SupplementDEX Database · Metabolic syndrome
4 references52.SupplementDEX Database: Metabolic syndrome — δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial2023
In MetS patients, combined δ-tocotrienol and resveratrol improved cardiometabolic risk factors versus placebo over the trial period.
53.SupplementDEX Database: Metabolic syndrome — Effect of resveratrol supplementation on hepatic steatosis and cardiovascular indices in overweight subjects with type 2 diabetes: a double-blind, randomized controlled trial2022
In 76 T2DM patients, resveratrol 1000 mg/day for 8 weeks improved hepatic steatosis indices and cardiovascular risk markers versus placebo.
54.SupplementDEX Database: Metabolic syndrome — No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial2017
In 74 men with metabolic syndrome, resveratrol 500 mg/day for 6 months did not improve inflammation, insulin sensitivity, or MetS criteria versus placebo.
55.SupplementDEX Database: Metabolic syndrome — Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion2014
In 24 metabolic syndrome patients, resveratrol 500 mg three times daily for 90 days improved insulin sensitivity and glucose control versus placebo.
SupplementDEX Database · Osteoarthritis
2 references56.SupplementDEX Database: Osteoarthritis — Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL)2024
In knee osteoarthritis patients, oral resveratrol in a patented formulation did not significantly reduce pain versus placebo in the ARTHROL phase 3 trial.
57.SupplementDEX Database: Osteoarthritis — Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study2018
In 110 knee osteoarthritis patients, resveratrol as meloxicam adjunct reduced pain and improved function versus meloxicam alone over 90 days.
58.SupplementDEX Database: Age-related cognitive decline — Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study2018
In 32 sedentary older adults over 90 days, resveratrol 300 or 1000 mg/day did not significantly improve cognitive test scores versus placebo.
59.SupplementDEX Database: Age-related cognitive decline — Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial2018
In 60 older adults over 26 weeks, resveratrol 200 mg/day did not significantly improve memory performance or hippocampal connectivity versus placebo.
60.SupplementDEX Database: Age-related cognitive decline — Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults2014
In 46 healthy older adults over 26 weeks, resveratrol 200 mg/day improved memory performance and hippocampal functional connectivity versus matched placebo controls.
SupplementDEX Database · Alzheimer's disease
1 reference61.SupplementDEX Database: Alzheimer's disease — Evidence of Clinical Efficacy and Pharmacological Mechanisms of Resveratrol in the Treatment of Alzheimer's Disease2023
A meta-analysis of resveratrol RCTs in Alzheimer disease found modest cognitive benefits in some trials, with pharmacological targets including SIRT1 and inflammatory pathways.
SupplementDEX Database · Beta-thalassemia
1 reference62.SupplementDEX Database: Beta-thalassemia — Efficacy and safety of resveratrol, an oral hemoglobin F-augmenting agent, in patients with beta-thalassemia intermedia2018
In 54 beta-thalassemia intermedia patients over 6 months, resveratrol did not significantly improve hemoglobin F levels versus hydroxyurea or placebo.
SupplementDEX Database · Breast cancer
1 reference63.SupplementDEX Database: Breast cancer — Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer2012
In women at increased breast cancer risk over 12 weeks, trans-resveratrol altered mammary promoter methylation patterns, suggesting possible chemopreventive biological activity.
Chronic obstructive pulmonary disease (COPD)
1 reference64.A resveratrol containing compound reduces oxidative stress and ameliorates clinical symptoms in COPD subjects. See external sourceExternal source
SupplementDEX Database · COVID-19
1 reference65.SupplementDEX Database: COVID-19 — Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)2022
In 100 COVID-19 outpatients, resveratrol plus vitamin D3 did not significantly reduce hospitalization, ER visits, or pneumonia versus placebo over 21 days.
SupplementDEX Database · High blood pressure
1 reference66.SupplementDEX Database: High blood pressure — The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. See external source2019
A meta-analysis in metabolic syndrome found resveratrol improved endothelial function in some trials but did not consistently lower blood pressure versus placebo.
View on PubMed2019
SupplementDEX Database · Liver health
1 reference67.SupplementDEX Database: Liver health — Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials2021
A meta-analysis found resveratrol supplementation significantly reduced ALT and AST in adults, suggesting modest liver enzyme improvements.
SupplementDEX Database · Migraine
1 reference68.SupplementDEX Database: Migraine — A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine2022
In 62 hormonal migraineurs, resveratrol for 3 months did not significantly reduce menstrual migraine burden index versus placebo in a crossover trial.
69.SupplementDEX Database: Mild cognitive impairment — Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment2017
In 40 mild cognitive impairment patients, resveratrol 200 mg/day for 26 weeks improved hippocampal connectivity and glucose control versus olive oil placebo.
70.SupplementDEX Database: Mitochondrial myopathy — No effect of resveratrol in patients with mitochondrial myopathy: A cross-over randomized controlled trial2021
In 11 mitochondrial myopathy patients, resveratrol 1000 mg/day did not improve exercise capacity versus placebo in a crossover trial.
71.SupplementDEX Database: Muscle mass & strength — The effect of dietary (poly)phenols on exercise-induced physiological adaptations: A systematic review and meta-analysis of human intervention trials2020
A meta-analysis found polyphenol supplementation did not enhance strength or VO2max gains from exercise training, though some recovery markers improved.
SupplementDEX Database · Oral health
1 reference72.SupplementDEX Database: Oral health — Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail2023
In chronic periodontitis patients after non-surgical therapy, resveratrol supplementation improved clinical attachment and reduced inflammatory markers versus placebo.
SupplementDEX Database · Osteopenia
2 references73.SupplementDEX Database: Osteopenia — Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial2023
In 60 postmenopausal women, equol plus resveratrol for 12 months improved bone turnover biomarkers versus placebo, without clear BMD changes.
74.SupplementDEX Database: Osteopenia — Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials2021
A meta-analysis found resveratrol did not significantly change bone mineral density overall, though some bone turnover markers improved.
SupplementDEX Database · Peritoneal dialysis
1 reference75.SupplementDEX Database: Peritoneal dialysis — Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study2016
In 72 PD patients, high-dose trans-resveratrol 450 mg/day improved ultrafiltration and angiogenesis-related markers versus low-dose or placebo over 12 weeks.
76.SupplementDEX Database: Rheumatoid arthritis — Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study2018
In an open-label burnout trial, Rhodiola rosea extract increased stress resistance and reduced burnout symptoms over treatment, supporting further randomized studies.
SupplementDEX Database · Sciatica
1 reference77.SupplementDEX Database: Sciatica — Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferol in Discogenic Sciatica in Young People: A Randomized Clinical Trial2023
In adults with stress-related fatigue, SHR-5 Rhodiola rosea extract improved fatigue and stress symptoms versus placebo in part I of the SHR-5 program.
78.SupplementDEX Database: Upper respiratory tract infection (URTI) — Effects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Β-Glucan in Preschool Non-Atopic Children with Wheezing2024
In chronically stressed adults, a magnesium-B-vitamin-rhodiola-green tea supplement reduced stress scores versus placebo over 28 days.