Oleic Acid
Oleic acid is the main monounsaturated fat in olive oil. Evidence often comes from dietary fat replacement rather than isolated supplements.
Overview
What is oleic acid?
Oleic acid is an omega-9 fatty acid found in high concentrations in olive oil.
Dosage
Typical dosing unavailable.
Effect graph
Effect heatmap
SupplementDEX Database
12 conditions for , and rated at least stars. All purchase bands. No minimum star filter.
Database Snapshot
Most oleic acid research is concentrated in a handful of conditions.
- Coronary heart disease accounts for 6 of 26 studies (23%).
- Bladder cancer accounts for 4 of 26 studies (15%).
- High cholesterol accounts for 4 of 26 studies (15%).
- Sparse coverage remains for Obesity, Breast cancer, Depression.
Dietary Sources
Top dietary sources
Food sources
Rich sources include vegetable oils.
Sources include Coconut oil, Cottonseed oil, Olive oil, Palm oil, and Rice bran oil.
Safety
Oleic acid is likely safe when used in amounts commonly found in the diet.
Frequently Asked Questions
References
Sources16 references
SupplementDEX uses only high-quality sources to determine supplement effectiveness.
SupplementDEX Database · Coronary heart disease
6 references1.SupplementDEX Database: Coronary heart disease — Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity2019
In 119 adults with central obesity, 6 weeks of canola or high-oleic canola oil diets lowered atherogenic lipids and apolipoproteins vs a Western fatty acid profile control.
2.SupplementDEX Database: Coronary heart disease — Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis2018
In 6568 MESA participants followed 13 years, top-quartile plasma oleic acid was associated with higher rates of coronary artery calcium, aortic valve calcification, and carotid plaque.
3.SupplementDEX Database: Coronary heart disease — Relation between plasma phospholipid oleic acid and risk of heart failure2018
In a nested case-control of men from the Physicians' Health Study, plasma phospholipid oleic acid was not significantly associated with incident heart failure across quartiles.
4.SupplementDEX Database: Coronary heart disease — DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial2014
In 130 adults with abdominal obesity in a 5-diet crossover, DHA-enriched high-oleic canola oil improved lipid profiles and predicted 10-year CVD risk compared with conventional canola and other test oils.
5.SupplementDEX Database: Coronary heart disease — Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study2011
In 7625 French adults from the Three-City Study, olive oil intake >0.5 tablespoon/day was associated with 41% lower stroke risk vs nonuse; higher plasma oleic acid also predicted lower stroke.
6.SupplementDEX Database: Coronary heart disease — Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils2009
A modeling meta-analysis estimated replacing trans-fat–containing oils with oleic-acid-rich fats reduces total and LDL cholesterol and coronary heart disease risk.
SupplementDEX Database · High cholesterol
2 references7.SupplementDEX Database: High cholesterol — High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects2011
In 36 hypercholesterolemic adults over 28 days per diet, high-oleic canola blended with flaxseed oil lowered LDL cholesterol 15.1% and total cholesterol 11% versus a Western diet.
8.SupplementDEX Database: High cholesterol — Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans1997
In 9 men with mild hypercholesterolemia, medium-chain triglyceride supplementation raised total and LDL cholesterol similarly to palm oil and above high-oleic sunflower oil.
SupplementDEX Database · Bladder cancer
1 reference9.SupplementDEX Database: Bladder cancer — Decreased Oleic Acid and Marine n - 3 Polyunsaturated Fatty Acids in Tunisian Patients with Urothelial Bladder Cancer2018
In 250 bladder cancer cases vs controls, higher plasma oleic, EPA, and DHA were associated with lower urothelial bladder cancer risk; higher palmitic acid and n-6:n-3 ratio raised risk.
SupplementDEX Database · Breast cancer
1 reference10.SupplementDEX Database: Breast cancer — Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies2016
A meta-analysis found higher total fat intake associated with 10% higher breast cancer risk (RR 1.10), but no significant associations for MUFA, PUFA, or oleic acid individually.
SupplementDEX Database · Depression
1 reference11.SupplementDEX Database: Depression — Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation2020
In 2793 SWAN perimenopausal women, higher dietary oleic and linoleic acid intake was associated with higher depression scores and greater odds of CES-D ≥16 in adjusted models.
SupplementDEX Database · Diabetes
1 reference12.SupplementDEX Database: Diabetes — Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus2001
In 8 type 2 diabetic patients, a 3-week low-fat diet enriched with oleic acid increased postprandial remnant lipoprotein cholesterol after an oral fat load vs linoleic-acid-enriched diet.
SupplementDEX Database · Diarrhea
1 reference13.SupplementDEX Database: Diarrhea — Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans2001
In 45 patients with chronic diarrhea, pre-meal oleic acid emulsion dose-dependently slowed gastrointestinal transit (29 to 83 min) and reduced stool frequency and volume.
SupplementDEX Database · Obesity
1 reference14.SupplementDEX Database: Obesity — Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity2016
In 101 adults with central obesity, 4 weeks of canola or high-oleic canola diets reduced android fat mass by ~3 kg vs high–saturated-fat blend, with BP and triglyceride benefits.
SupplementDEX Database · Pancreatic cancer
1 reference15.SupplementDEX Database: Pancreatic cancer — Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study2018
In 23,658 EPIC-Norfolk participants (88 pancreatic cancers), higher dietary oleic acid intake was inversely associated with pancreatic cancer risk, especially in non-obese participants.
SupplementDEX Database · Ulcerative colitis
1 reference16.SupplementDEX Database: Ulcerative colitis — Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries2014
In 26 incident ulcerative colitis cases vs 639 controls, higher dietary arachidonic acid was associated with increased UC risk and oleic acid with lower risk in a prospective cohort.