Vaginal atrophy

Overview

Vitamin D has been studied for vaginal atrophy by mouth and as vaginal suppositories, with mixed results. Oral vitamin D for at least one year improved vaginal cell health in postmenopausal women in one small study but did not change symptoms compared with no supplementation.

Vaginal vitamin D suppositories daily for eight weeks improved cell health and symptoms in women with breast cancer taking tamoxifen compared with placebo. Vitamin D carries low ratings overall. See the heatmap and evidence reviews below for more detail.

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Vitamin D	★★★★★	Low

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Studies

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1 supplement for rated at least stars. All purchase bands. No minimum star filter.

Vitamin DView supplement →

Reconsider purchase★★★★★

How we scored this

Effect SizeLowEvidenceLowTrustMedium

Evidence Review

It is not clear if taking vitamin D by mouth helps with vaginal atrophy.
One small study found that postmenopausal women who took vitamin D for at least a year had healthier vaginal cells, but their symptoms were the same as women who did not take vitamin D. In women with breast cancer taking tamoxifen, using vitamin D vaginal suppositories daily for 8 weeks helped improve vaginal cell health and symptoms compared to placebo.

Browse 2 studies

RCTThe effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer2019

An 8-week study in women with breast cancer on tamoxifen found vitamin D and E vaginal suppositories improved tamoxifen-induced vaginal atrophy versus control.

Effect: Benefit
Duration: 8 weeks
Population: Women

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ObservationalThe effects of postmenopausal Vitamin D treatment on vaginal atrophy2004

A cross-sectional study of 60 postmenopausal women found calcitriol treatment associated with lower vaginal atrophy symptoms versus untreated controls.

Effect: Benefit
Population: Postmenopausal women

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Evidence visualised

Same ratings as above, aggregated so you can see coverage and imbalance.

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Effect-size distribution

How large the reported benefits tend to be

Study distribution across 1 supplements for vaginal atrophy (2 studies total).
Supplement	DEX	Studies	Meta-analyses	Share
Vitamin D	★★★★★44%	2	0	100%

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Overview

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