Retinopathy of prematurity
Supplements studied for retinopathy of prematurity.
Overview
Multiple supplements have been studied for retinopathy of prematurity (ROP) in preterm infants, but most show no clear benefit. Lutein (4 studies), Zeaxanthin (4 studies), Vitamin A (4 studies), Inositol (3 studies), and Algal Oil (1 study) do not appear to reduce ROP risk or severity in current trials. Myo-inositol may even increase adverse outcomes in one large study.
One very small Vitamin A trial reported risk reduction with high-dose drops, but this requires confirmation. See the heatmap and evidence reviews below.
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